A simple and expedient method for the stepwise synthesis of 2-ethoxy-(4H)-3,1-benzoxazine-4-ones  

作　　者：Asrin Bahmani Mahnaz Sharafi-Kolkeshvandi Farzad Nikpour 

机构地区：[1]Department of Chemistry,Faculty of Sciences,University of Kurdistan,P.O.Box 66315-416,Sanandaj,Iran

出　　处：《Chinese Chemical Letters》2012年第4期434-437,共4页中国化学快报（英文版）

基　　金：the University of Kurdistan Research Council for the partial support of this work

摘　　要：A simple and practical route is described for the synthesis of 2-efhoxy-（4H）-3,1 -benzoxazine-4-ones using the coupling reaction of anthranilic acid derivatives with diethyl dicarbonate following with fast cyclization of the carbamate adduct with a dehydrocyclization agent such as cyanuric chloride and N,N′-dicyclohexylcarbodiimide in PEG at room temperature.High yields of the products obtained under mild reaction conditions with simple work-up of the reaction mixture.A simple and practical route is described for the synthesis of 2-efhoxy-（4H）-3,1 -benzoxazine-4-ones using the coupling reaction of anthranilic acid derivatives with diethyl dicarbonate following with fast cyclization of the carbamate adduct with a dehydrocyclization agent such as cyanuric chloride and N,N′-dicyclohexylcarbodiimide in PEG at room temperature.High yields of the products obtained under mild reaction conditions with simple work-up of the reaction mixture.

关 键 词：2-Ethoxy-（4H）-3 l-benzoxazine-4-ones Diethyl dicarbonate Cyanuric chloride N N′-Dicyclohexylcarbodiimide Dehydrocyclization reagent 

分 类 号：O626[理学—有机化学]