纳洛酮对重度酒精中毒患者在院前急救中的应用  

Clinical research of naloxone on severe alcoholism patients in the pre-hospital first aid

作　　者：黄敏坚[1] 张远新[1] 

机构地区：[1]广州医学院第一附属医院,510120

出　　处：《中国现代药物应用》2012年第7期5-6,共2页Chinese Journal of Modern Drug Application

摘　　要：目的评价纳络酮对重度酒精中毒患者在院前急救中的疗效。方法对院前急救中重度酒精中毒患者60例,在现场常规治疗的基础上,给予静脉滴注盐酸纳洛酮0.8mg,然后按1.2mg/h速度加入补液中静脉滴注(生理盐水或5%葡萄糖盐水)。观察起效时间、血氧饱和度(SpO2)、清醒时间等临床效果及有无不良反应。选择既往40例仅予常规治疗的急性重度酒精中毒患者作为对照组,进行比较分析。结果应用纳洛酮后,SpO2恢复至95%以上时间为(6.0±1.5)min,清醒时间为(15.7±4.5)min,对照组SpO2至95%以上时间为(8.5±1.5)min,清醒时间为(24.5±3.0)min。两组比较具有统计学差异(P<0.05)。结论纳洛酮在院前急救中对急性重度酒精中毒具有明显疗效,且无明显的不良反应。Objective To evaluate the effects of naloxone on severe alcoholism patients in pre-hospital first aid.Methods 60 cases of severe alcoholism in pre-hospital first aid,on the basis of routine treatment,intravenous injection of naloxone hydrochloride in 0.8 mg,and then press 1.2 mg/h speed to join in intravenous rehydration（saline or 5% glucose saline）.Observation on the onset time,oxygen saturation（SpO2）,waking time,clinical effect and had no adverse reaction.Selected previous 40 cases only received routine treatment of acute alcoholism patients as control group,comparative analysis.Results After naloxone threatment,SpO2 back to more than 95% times for（6.0±1.5）min,（15.7±4.5）min awake time,control group SpO2 to more than 95% time of（8.5±1.5）min,（24.5±3.0）min awake time.The two groups had significant difference（P0.05）.Conclusion Naloxone in pre-hospital care on acute severe alcoholism has obvious therapeutic effect,and no obvious adverse reaction.

关 键 词：纳洛酮 酒精中毒 院前急救 

分 类 号：R595.6[医药卫生—内科学]