阴沟肠杆菌感染的临床分布与耐药性分析  

Distribution and drug resistance of enterobacter cloacae from clinic

作　　者：沈映冰[1] 黄健宇[2] 杜玲[2] 赖在真[2] 

机构地区：[1]中山大学附属第六医院药剂科 [2]中山大学附属第一医院东山院区检验科

出　　处：《中国现代药物应用》2012年第7期6-7,共2页Chinese Journal of Modern Drug Application

摘　　要：目的了解阴沟肠杆菌的临床分布状况及耐药性,为临床治疗阴沟肠杆菌的感染提供参考。方法用WHONET5.4统计软件回顾性分析阴沟肠杆菌的分布及抗菌药物耐药性状况。结果 2006年1月至2009年6月共分离出233株阴沟肠杆菌,菌株来源主要为痰液、尿液、伤口分泌物,分别占24.9%、19.3%、14.2%;阴沟肠杆菌对碳青酶烯类、阿米卡星、头孢吡肟、头孢唑肟、哌拉西林/他唑巴坦的敏感性较高。结论阴沟肠杆菌主要引起呼吸道、尿道和创伤感染;对三代头孢菌素耐药严重,呈多药耐药性,亚胺培南、四代头孢菌素仍为治疗阴沟肠杆菌严重感染的首选用药。Objective To investigate the clinical distribution and antimicrobial resistance of infections caused by Enterobacter cloacae in our hospital for guiding the clinical application of antibiotics reasonably.Methods Retrospective analysis was performed to analyze the distribution and drug-resistance of Enterobacter cloacae by statistics software WHONET 5.4.Results Totally 233 strains of E.cloacae were isolated between January 2006 and September 2009.The percentages of these strains isolated from sputum,urine and wound secretion were 24.9%,19.3%,14.2%.Enterobacter cloacae was more sensitive to Carbapenems,Amikacin,Cefepime,Ceftizoxime and Piperacillin/Tazobactam.Conclusion Enterobacter cloacae mainly causes infections of respiratory tract,urinary tract and wound infection in clinic.E.cloacae is multidrug resistant and severely resistant to third generation cephalosporins.Imipenem and fourth generation cephalosporins remain to be the first choice to treat the severe infection caused by E.cloacae.

关 键 词：阴沟肠杆菌 耐药性 医院感染 

分 类 号：R446.5[医药卫生—诊断学]