职业性氟接触者的血清免疫球蛋白和几种酶活性改变及抗氟灵干预效果分析  

Changes of Serum immunoglobulin level and enzyme activity in occupational fluorine exposers and the effect analysis of “Kang Fu Ling” intervention

作　　者：李克俊 黄志军 杨岩 付强祖 高华 肖朝阳 郭海燕 

机构地区：[1]中国长城铝业公司总医院,河南省郑州市450041 [2]河南省职业病防治所

出　　处：《中国职业医学》2000年第2期28-30,共3页China Occupational Medicine

摘　　要：目的　弄清过量氟摄入对机体的影响及干预作用。方法　选取职业性氟接触者 ,工龄 10年以上自愿者男工 60名 ,分两组。 3 0人服抗氟灵冲剂 ,3 0人服安慰剂。结果　氟接触者尿F-、血F-、尿BF4 -较非接氟者明显增多。血清IgG、IgM、IgA前者相对较低 ,AKP则明显高于后者 ,SOD活性各组间无明显差异 ,GSH Px活性前者明显低于后者。服用抗氟灵组较安慰剂组尿氟化硼排出量增加 ,且血清IgM含量、GSH Px活性升高。结论　过量氟可致机体血清免疫球蛋白和AKP、GSH Px等活性改变。抗氟灵干预有降低氟负荷。Objective In order to find out the influence and intervention function of excessive fluorine to human body.Methods Sixty voluntary male occupational fluorine exposers of ten years' standing were chosen and divided equally into two groups. One group was given “KFL” and the other placebo. Another 30 non fluorine exposers were choser as control.Results Fluorine exposers' urine F -, blood F - and urine BF - 4 were obviously higher than non fluorine exposers. The former's serum IgG, IgM and IgA were relatively low but AKP was much higher than the latters. There was not obvious difference in SOD activities between these groups, but the formers GSH Px activity was obviously lower than that of the latter. The “KFL” group excreted much urine boron fluoride than the placebo group, and the serum IgM content and GSH Px activity also increased. Conclusion Excessive fluorine can change human bodys serum immunoglobulin level and AKP, GSH Px activities. “KFL” intervention can lower the fluorine burden and protect humans health.

关 键 词：职业性氟接触 抗氟灵 免疫球蛋白 GSH-PX AKP 

分 类 号：R135[医药卫生—劳动卫生]