清肺消炎丸体外抗菌活性研究  

Antibacterial activity of Qingfei Xiaoyan Pills in vitro

作　　者：白芳[1] 荣子丹[2] 白钢[1] 侯媛媛[1] 

机构地区：[1]南开大学药学院,天津300071 [2]天津中新药业集团股份有限公司达仁堂制药厂,天津300457

出　　处：《药物评价研究》2012年第2期106-108,共3页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(21002052);天津市应用基础及前沿技术研究计划(10JCYBJC14300)

摘　　要：目的观察清肺消炎丸对9种肺炎常见病原菌的体外抗菌作用。方法采用琼脂稀释法,测定清肺消炎丸对9种药敏质控菌株的最低抑菌浓度(MIC)及最低杀菌浓度(MBC)。结果清肺消炎丸对肺炎链球菌、化脓性链球菌、金黄色葡萄球菌、流感嗜血杆菌的MIC分别为6.25、25、25、50mg/mL,相应的MBC分别为12.5、25、50、50mg/mL;对大肠杆菌、铜绿假单胞菌、肺炎克雷伯菌、变形杆菌及白色念珠菌均无明显体外抑菌活性。结论清肺消炎丸对肺炎链球菌、化脓性链球菌、金黄色葡萄球菌、流感嗜血杆菌具有体外抗菌作用,其中对链球菌的抗菌活性较高。Objective To study the antibacterial effect of Qingfei Xiaoyan Pills. Methods By using test agar plates serial dilution method, the minimum inhibition concentration （MIC） and minimal bactericidal concentration （MBC） of different dilution degrees of Qingfei Xiaoyan Pills on Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Streptococcus pneumoniae, Escherichia coli, Proteusbacillus vulgaris, Haemophilus influenza, Streptococcus pyogeones, and Canidia albicans were determined. Results The MICs of Qingfei Xiaoyan Pills to Streptococcus pneumoniae, Streptococcus pyogeones, Staphylococcus aureus, and Haemophilus influenza were 6.25, 25, 25 and 50 mg/mL, respectively, while the MBCs were 12.5, 25, 50 and 50 mg/mL, respectively. Conclusion Qingfei Xiaoyan Pills could effectively inhibit Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogeones and Haemophilus influenza. Among them, Qingfei Xiaovan Pills are more effective for Streptococcus.

关 键 词：清肺消炎丸 最低抑菌浓度 最低杀菌浓度 

分 类 号：R978.19[医药卫生—药品]