3,6-(二甲氨基)-二苯并碘杂六环葡萄糖酸盐对大鼠局灶性脑缺血再灌注损伤的保护作用  

Protective effects of 3,6-dimethamidodibenzopyriodonium gluconate on focal cerebral ischemia-reperfusion injury in rats

作　　者：邓秀玲[1] 钱之玉[1] 刘乃丰[2] 侯自杰[3] 马小亚[4] 王美纳[4] 

机构地区：[1]中国药科大学药理学教研室,江苏南京210009 [2]南京铁道医学院心血管内科,江苏南京210009 [3]兰州大学化学系,甘肃兰州730003 [4]西安医科大学第二临床医学院临床药理研究室,陕西西安710004

出　　处：《中国药理学与毒理学杂志》2000年第2期131-135,共5页Chinese Journal of Pharmacology and Toxicology

摘　　要：在大鼠可逆性大脑中动脉梗死模型上观察了3,6- (二甲氨基 ) -二苯并碘杂六环葡萄糖酸盐 ( I- 93)对局灶性脑缺血再灌注损伤的影响 .缺血前 1 0 minip I- 930 .1 2 5,0 .2 5,0 .5mg· kg-1呈剂量依赖性抑制缺血 3h再灌注 3h所引起的血清乳酸脱氢酶和肌酸激酶活性的升高 ,缩小脑梗死范围 ,降低大鼠死亡率 ,改善脑超微结构损害 .结果表明 I- 93对缺血再灌注引起的脑损伤具有保护作用 .Effects of 3,6 dimethamidodiben zopyriodonium gluconate(I 93) on focal cerebral ischemia reperfusion injury were studied in reversible cerebral middle artery occlusion model without craniectomy in rats. I 93 0.125,0.25 and 0.5 mg·kg -1 ip at 10 min before ischemia dose dependently inhibited the elevation of lactate dehydrogenase and creatine kinase activities in serum induced by cerebral ischemia for 3 h followed by reperfusion for 3 h, decreased the size of cerebral infarction and mortality of animal. I 93 0.5 mg·kg -1 also improved the brain ultrastructure damage. These results indicate that I 93 has protective effects against cerebral ischemia reperfusion injury.

关 键 词：二苯骈碘杂六环 葡萄糖酸盐 脑缺血 再灌注损伤 

分 类 号：R96[医药卫生—药理学]