The clinical significance evaluation of serum β_2-microglobulin for thyroid cancer patients  

甲状腺癌血清β_2-MG临床意义评估(英文)

作　　者：Shihong Ma Qinjiang Liu Kesheng Li 

机构地区：[1]Department of Head and Neck Srugery,The Cancer Hospital of Gansu Province,Lanzhou 730050,China

出　　处：《The Chinese-German Journal of Clinical Oncology》2012年第5期271-273,共3页中德临床肿瘤学杂志（英文版）

摘　　要：Objective： The aim of this study was to investigate the clinical value and relevance on the serum β2-microglobulin （β2-MG） of patients with thyroid cancer. Methods： One thousand and two normal cases, 95 thyroid cancer patients and 243 nodular goiter patients were selected to measure serum β2-MG levels using double-antibody sandwich enzyme-linked immunosorbent assay （ELISA）. Results： The positive rate of 7.78% in normal population （78/1002） and 31.57% in thyroid cancer patients （30/95）. There were significant differences between the normal population and thyroid cancer patients （X2 = 55.352; P = 0.000）. The positive rate of 7.81% in nodular goiter patients （19/243） and there were no significant differences between the normal population and nodular goiter patients （X2 = 0.0004; P = 0.986）, but significant differences between nodular goiter patients and thyroid cancer patients （x2 = 31.106; P = 0.000）. Meanwhile, the significant difference of the positive rate existed in between the various pathological types of thyroid cancer （X2 = 10.015; P = 0.007）, anaplastic thyroid cancer patients with the highest positive rate and The significant difference was found between the positive lymph node metastasis groups and negative lymph node metastasis groups （x2 = 4.441; P = 0.035）, the presence of distant metastasis group and absence of distant metastasis group （X2 = 9.795; P = 0.002）. Conclusion： Serum β2-MG levels and prognosis of thyroid cancer patients was negatively correlated. It showed important clinical value to detect the level of β2-MG in the early diagnosis, prognosis and the clinical observation for thyroid cancer patients.

关 键 词：thyroid cancer β2-microglobulin （β2-MG） enzyme-linked immunosorbent assay （ELISA） test 

分 类 号：S858.28[农业科学—临床兽医学] X503.1[农业科学—兽医学]