Sweet综合征的临床相关进展  

Clinical progress in Sweet syndrome

作　　者：宋志强[1] 

机构地区：[1]第三军医大学西南医院皮肤科,重庆400038

出　　处：《皮肤病与性病》2012年第2期77-79,共3页Dermatology and Venereology

摘　　要：Sweet综合征又称急性发热性嗜中性皮病,是一种少见的、病因尚未完全阐明的反应性疾病。临床上分为经典型/特发型、恶性肿瘤相关型和药物诱导型三个类型,以发热、疼痛性红色斑块、血中嗜中性粒细胞升高和真皮内中性粒细胞浸润为特征,可与多种炎症性疾病或肿瘤伴发。组织学上主要表现为真皮弥漫性成熟中性粒细胞浸润、白细胞核碎裂、真皮乳头水肿,通常缺乏表皮和原发性白细胞破碎性血管炎的改变。系统性糖皮质激素可快速缓解皮肤和系统症状。本文对Sweet综合征的相关进展作综述。Sweet＇s syndrome, also known as acute febrile neutrophilic dermatosis, is an uncommon disease with un-known pathogenesis. It was characterized by the sudden onset of fever, painful erythema with elevated borders and in-filtration of neutrophil granulocytes. This syndrome can be classified into three clinical types, including classical or idiopathic Sweet＇s syndrome, malignancy-associated Sweet＇s syndrome and drug induced Sweet＇s syndrome. The main histological feature is a massive infiltration of neutrophils in the dermis and dermal edema, without changes of the epidermis and vasculitis. Application of systemic corticosteroids would relieve the cutaneous and systemic symp-toms. The clinical progress in Sweet syndrome was reviewed in this paper.

关 键 词：SWEET综合征 急性发热性嗜中性皮病 嗜中性皮病 

分 类 号：R543[医药卫生—心血管疾病]