Environmental Friendly Synthesis of Novel Isatin Ketal and Isatin Schiff Base Derivatives Using Michael Addition Reaction under Solvent-Free Conditions  

作　　者：Imanzadeh,Ghotamhassan Soltanizadeh,Zahra Khodayari,Ali Zamanloo,Mohammadreza Mansoori,Yagoub Salehzadeh,Jaber 

机构地区：[1]Department of Chemistry,Faculty of Science,University of Mohaghegh Ardabili,56199-11367,Ardabil,Iran

出　　处：《Chinese Journal of Chemistry》2012年第4期891-899,共9页中国化学（英文版）

摘　　要：An efficient and simple procedure for the synthesis of novel isatin derivatives is described. Michael addition of aniline Schiff bases of isatin or p-toluidine Schiff bases of isatin to fumaric esters affords the Michael adduct com- pounds in good to high yields in the presence of K2CO3 and tetrabutylammonium bromide （TBAB） under sol- vent-free conditions. Repeating of this reaction about spiro[l,3-dioxolane-2,3＇-indol]-2＇（l＇H）-one, as a Michael do- nor, in the presence of 1,4-diazabicyclo[2.2.2]octane （DABCO） gives Michael adducts in remarkable yields under the same conditions.An efficient and simple procedure for the synthesis of novel isatin derivatives is described. Michael addition of aniline Schiff bases of isatin or p-toluidine Schiff bases of isatin to fumaric esters affords the Michael adduct com- pounds in good to high yields in the presence of K2CO3 and tetrabutylammonium bromide （TBAB） under sol- vent-free conditions. Repeating of this reaction about spiro[l,3-dioxolane-2,3＇-indol]-2＇（l＇H）-one, as a Michael do- nor, in the presence of 1,4-diazabicyclo[2.2.2]octane （DABCO） gives Michael adducts in remarkable yields under the same conditions.

关 键 词：Michael addition isatin ketal isatin Schiffbase fumaric ester acrylic ester solvent-free conditions 

分 类 号：TQ244.2[化学工程—有机化工] O621.256.7[理学—有机化学]