Spectral Characterization and Antimicrobial Activity of Some Schiff Bases Derived from 4-Methyl-2-aminophenol  

作　　者：Gurbuz, Demet Cinarli, Adem Tavman, Aydin Birteksoz, A. Seher 

机构地区：[1]Department of Chemistry, Faculty of Engineering, Istanbul University, 34320, Avcilar, Istanbul, Turkey [2]Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34452, Beyazit, Istanbul, Turkey

出　　处：《Chinese Journal of Chemistry》2012年第4期970-978,共9页中国化学（英文版）

摘　　要：A series of N-（5-methyl-2-hydroxyphenyl）-（2/3/4/5-substituted）-benzaldimines （I--XlII） were synthesized us- ing appropriate synthetic route. Their structures were characterized by FT-IR, UV-Visible, ESI-MS, 1H- and 13C-NMR spectroscopic techniques and analytical methods. The crystal structure of N-（5-methyl-2-hydroxyphenyl）- 3,4-dimethoxybenzaldimine （XIII） was determined by X-ray diffraction at room temperature. Relationship between the melting points and the structures of the compounds were examined. Antibacterial activities of the compounds were evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumo- niae, Pseudomonas aeruginosa and Proteus mirabilis. Antifungal activities were reported for Candida albieans. Some of the Schiffbases showed considerable antimicrobial activity against S. aureus and C. albicans.A series of N-（5-methyl-2-hydroxyphenyl）-（2/3/4/5-substituted）-benzaldimines （I--XlII） were synthesized us- ing appropriate synthetic route. Their structures were characterized by FT-IR, UV-Visible, ESI-MS, 1H- and 13C-NMR spectroscopic techniques and analytical methods. The crystal structure of N-（5-methyl-2-hydroxyphenyl）- 3,4-dimethoxybenzaldimine （XIII） was determined by X-ray diffraction at room temperature. Relationship between the melting points and the structures of the compounds were examined. Antibacterial activities of the compounds were evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumo- niae, Pseudomonas aeruginosa and Proteus mirabilis. Antifungal activities were reported for Candida albieans. Some of the Schiffbases showed considerable antimicrobial activity against S. aureus and C. albicans.

关 键 词：SCHIFFBASES methylhydroxyphenyl SPECTROSCOPY X-ray diffraction ANTIMICROBIAL 

分 类 号：TQ246.35[化学工程—有机化工] O614.711[理学—无机化学]