亚硒酸钠拮抗烹调色拉油烟冷凝物致小鼠毒性作用的研究  

ANTAGONISTIC EFECTS OF SODIUM SELENITE ON TOXICITY OF SALAD OIL VAPOR CONDENSATE IN MICE

作　　者：周纯先[1] 肖棣[1] 王帮霞[1] 

机构地区：[1]蚌埠医学院卫生学教研室,安徽蚌埠233003

出　　处：《癌变．畸变．突变》2000年第1期39-42,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的 :实验观察亚硒酸钠对色拉油烟冷凝物致小鼠毒性作用的影响。方法 :采用微核试验和精子畸形分析方法 ,对亚硒酸钠拮抗烹调色拉油烟冷凝物致小鼠微核率和精子畸形率的作用进行了实验观察。试验资料采用U检验分析。结果 :小鼠灌胃给予烹调色拉油烟冷凝物 5ml/kg和 10ml/kg体重 15d后 ,其微核率和精子畸形率显著地高于 2 .5ml/kg组和单纯色拉油对照组 (P <0 .0 1) ,而 2 .5ml/kg组上述两项指标与对照组差异无显著性 (P >0 .0 5 )。结果还显示 ,若同时给小鼠补充亚硒酸钠 1.0mg/kg体重后 ,可使烹调色拉油烟冷凝物 (5ml/kg体重 )致小鼠微核率和精子畸形率的作用明显减弱。 结论 :烹调色拉油烟冷凝物对小鼠具有明显地毒性作用 ,而补充亚硒酸钠则可降低其作用。Purpose: To study the effect of sodium selenite on the toxicity of salad oil vapor condensate in mice. Methods: The antagonistic effects of sodium selenite on the rate of micronucleus and of sperm deformity in mice were abserved with the microunucles test and the sperm deformity analysis. The experimental data were calculated by statistical in U test. Results: The rate of micronucleus and of sperm deformity of mice treated with salad oil vapor condensate at 5ml/kg and 10ml/kg groups was abviously higher than that of 2.5ml/kg and conevol groups (P<0.01). After the mice were suplied sodinm selenite at 1.0mg/kg, the rate of micronucleus and of sperm deformity was significantly lower than that of salad oil vapor condensate group (P<0.01). Conclusion: The antagonistic effects of sodium selenite on the toxicity of salad oil vapor condensate was significant in mice.

关 键 词：亚硒酸钠 色拉油烟 冷凝物 毒性 

分 类 号：R994.6[医药卫生—毒理学] R992[医药卫生—药学]