A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B)  

作　　者：YANG ErXia ZHAO Heng ZHANG Ying LIU JianSheng LIAO Yun WANG LiChun CUI PingFang YANG LiXian LIU LongDing DONG ChengHong DONG ShaoZhong SHAO CongWen JIANG Li SUN Le LI QiHan 

机构地区：[1]Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming 650118, China [2]jiangsu Convax Biotechnology Co., Ltd., Taizhou 225300, China

出　　处：《Science China(Life Sciences)》2012年第4期336-342,共7页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of China (Grant No. 2011CB504903);the National Natural Science Foundation of China (Grant No. 81171573);the Important National Science & Technology Specific Projects (Grant No. 2009ZX10004-308);the General Program of Applied Basic Research Programs Commission, Foundation of Yunnan Province (Grant No. 2011FB116)

摘　　要：Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains' biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5′ non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity.Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease （HFMD）. The etiological characteristics of Coxsackie A virus type 16 （CA16） are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains＇ biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5＇ non-coding region of the viral genome and the VP1 structural region se- quence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their patho- genicity.

关 键 词：CA16 strains proliferation kinetics PATHOGENICITY 

分 类 号：S855.3[农业科学—临床兽医学] Q784[农业科学—兽医学]