血浆置换治疗病毒性重型肝炎各项指标与临床观察  

Changes of laboratory indexes and prognosis with severe hepatitis B before and after plasma exchange

作　　者：皮佑珺[1] 润袁敏[1] 饶绘[1] 钟万芬[1] 

机构地区：[1]襄樊学院附属襄阳市中心医院医学检验部,湖北襄阳441021

出　　处：《临床血液学杂志（输血与检验）》2012年第2期223-224,共2页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:观察血浆置换(PE)治疗病毒性重型肝炎的各项指标变化和临床疗效。方法:随机抽取40例病毒性重型肝炎患者在内科综合治疗的基础上加用PE治疗,对照组35例病毒性重型肝炎患者仅行内科综合治疗,观察PE组治疗前后肝功能、凝血指标变化;比较PE组和对照组临床疗效。结果:实验组治疗后血清胆红素、谷丙转氨酶等明显下降,γ谷氨酰转肽酶和白蛋白未见明显变化;除白陶土部分凝血时间未见明显变化外,凝血指标有所好转;PE组治疗有效率为62.5%,高于对照组(51.4%)(P<0.05)。结论:血浆置换治疗病毒性重型肝炎能明显改善肝功能和凝血功能,提高治疗有效率。Objective：To observe the effect of plasma exchange （PE）on indexes of liver and coagulation func- tion and prognosis in patients with severe hepatitis B. Method：Among 75 patients with severe hepatitis B, 40 cases treated with PE on the basic medical therapy , 35 cases were treated with only basic medical therapy as control group. The indexes of liver and coagulation function were assessed, Result：The indexes of bilirubin （Bil） and ala- nine transaminase （ALT） decreased（ P〈0. 01）and PTA increased （P〈0. 01） after PE. The PE could increase the treat effective rate compare with controls （P〈0.05）. Concluston：Plasma exchange might be an effective thera- py for severe hepatitis B ,and could improve the liver function and coagulation function and increase the survival rate of patients with severe hepatitis B.

关 键 词：重型肝炎 血浆置换 

分 类 号：R512.6[医药卫生—内科学]