抗病毒RNA沉默和病毒拮抗RNA沉默策略研究进展  

Antiviral RNA Silencing and Virus Strategies for Silencing Suppression

作　　者：施艳[1] 韩卫丽[1] 孙虎[2] 王振跃[1] 

机构地区：[1]河南农业大学植物保护学院,河南郑州450002 [2]河南省农业科学院,河南郑州450002

出　　处：《河南农业科学》2012年第4期7-11,共5页Journal of Henan Agricultural Sciences

基　　金：河南省重点科技攻关项目(072102160007)

摘　　要：RNA沉默通指在转录或转录后水平上由RNA介导、序列特异性地降解靶标RNA从而抑制基因表达的过程。在动物、真菌和植物中,RNA沉默是通过小RNA的形成来抵御病毒侵染的,病毒自身可以作为RNA沉默的诱导子和靶标。病毒通过进化形成积极的和消极的策略来对抗RNA沉默。为此,主要讨论了siRNAs和miRNAs介导的抗病毒RNA沉默以及病毒蛋白和RNA介导的沉默抑制作用,有助于阐明病毒侵染与寄主之间的相互关系,为抗病毒研究奠定基础。RNA silencing refers to diverse RNA-directed processes resulting in sequence-specific degradation of target RNA and repression of gene expression either at transcriptional,posttranscriptional or translational levels.In animals,fungi and plants,RNA silencing represents a mechanism guided by small RNAs against virus infection.Viruses can be inducers and targets of RNA silencing,and have evolved active and passive strategies to counter the cellular antiviral mechanism.This review discusses siRNAs-and miRNAs-mediated antiviral RNA silencing and virus strategies for silencing suppression in order to further clarify the relationship between virus infection and host.

关 键 词：RNA沉默 抗病毒 沉默抑制 小RNA 

分 类 号：Q939.4[生物学—微生物学]