益气活血解毒汤药治疗酒精性肝硬化患者内毒素血症疗效观察  

Clinical observation of endotoxaemia due to alcoholic cirrhosis treated by Yiqihuoxuejiedu herb

作　　者：来要良[1] 杨晋翔[1] 李秀惠[2] 

机构地区：[1]北京中医药大学第三附属医院 [2]首都医科大学附属北京佑安医院

出　　处：《中西医结合肝病杂志》2012年第2期85-86,109,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：北京中医药大学自主课题(No.2010-JYBZZ-XS080;2011-JYBZZ-DS112)

摘　　要：目的:观察益气活血解毒汤药治疗酒精性肝硬化内毒素血症的疗效。方法:采用随机、对照的观察方法,将60例患者分为对照组和治疗组,治疗组在基础支持治疗基础上采用益气活血解毒法汤药,对照组采用基础支持治疗。经过4周治疗,通过症状积分、化验指标,观察酒精性肝硬化内毒素血症的疗效。结果:经过治疗后,两组患者的总体临床症状积分、尤其是乏力积分得到明显改善(P<0.05);总胆红素(TBil)、谷氨酰转肽酶(GGT)、凝血酶原活动度(PTA)、血氨(NH3)、内毒素(ET)水平及总体疗效等优于对照组(P<0.05)。结论:益气活血解毒汤药可改善酒精性肝硬化内毒素血症患者的临床症状、肝功能、凝血功能及内毒素水平,是治疗酒精性肝硬化内毒素血症的有效方药。Objective： To explore the effect of Yiqihuoxuejiedu in the treatment of alcoholic cirrhosis with endotoxaemia. Methods： Sixty patients were randomly divided into the experimental group （n = 30） and the control group （n = 30） . The experimental group was given Yiqihuoxuejiedu herb and basic therapy, and the control group was given basic therapy for 4 weeks. The improvement of clinical symptoms was evaluated by clinical symptom score. Results： After 4 weeks＇treatment, the main symptom scores of both groups were significantly lower than those before the treatment （ P 〈 0. 05 ）, and the alleviation of assay index such as TBil, GGT, PTA, NH3, ET, of experimental group was significantly better than that of control group （P 〈0. 05） . Conclusion： Yiqihuoxuejiedu is more effective in patients with endotoxaemia of alcoholic cirrhosis than control group.

关 键 词：酒精性肝硬化 内毒素血症 益气活血解毒 

分 类 号：R259[医药卫生—中西医结合]