补虚颗粒成型工艺研究  

Study on formation process for buxue granules

作　　者：耿丽[1] 时晓亚[1] 

机构地区：[1]湖北医药学院附属东风医院,湖北十堰442008

出　　处：《中医药导报》2012年第4期76-77,共2页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨补虚颗粒的成型工艺条件。方法:以稀释剂种类、浸膏粉与稀释剂的比例、乙醇浓度及干燥温度为考察因素,以成型性、溶解性和有效成分保留率为指标,采用正交试验优选最佳成型工艺。结果:最佳制粒工艺为采用可溶性淀粉作为稀释剂,浸膏粉与可溶性淀粉比例为1∶1.5,用95%乙醇作为润湿剂制粒,60℃干燥颗粒。结论:本法确定成型工艺制备的颗粒剂溶解性好、有效成分保留率高,可为其生产提供依据。Objeetive： To ascertain the best formation process of buxue granules. Method： The formation process of buxue granules was optimized by orthogonal experiment design using type of diluent,ratio of dry extract to soluble starch, concentra- tion of ethanol,drying temperature as factors with eligible ratio,solution and retention rate as index. Result： The optimal forming process were as follows： soluble starch was used as diluent, ratio of dry extract to soluble starch was 1：1.5, 95% ethanol was used as wetting agent, drying temperature was 60℃. Conclusion： Prepared granules have good solubility with the high re- tention rate of active component.The formation process is available for the development and production of buxue granules.

关 键 词：补虚颗粒 成型工艺 正交设计 高效液相色谱法 

分 类 号：R284.3[医药卫生—中药学]