Phen-Fe_3O_4/PLA-PEG-PLA微球的制备、表征及体外释放行为  

Preparation,Characterization and in Vitro Release Behavior of Phen-Fe_3O_4/PLA-PEG-PLA Microspheres

作　　者：李亚瑜[1] 毛晓颖[1] 汪凌[1] 甄卫军[1] 

机构地区：[1]新疆大学化学化工学院,乌鲁木齐830046

出　　处：《材料导报》2012年第8期85-88,101,共5页Materials Reports

基　　金：2005年度新疆维吾尔自治区高校科研计划(XJEDU2005E01)

摘　　要：采用微波合成的PLA-PEG-PLA和单微乳法制备的纳米Fe3O4为载体,以邻菲罗啉(1,10-Phenanthro-line,Phen)为释放模型药物,通过乳化-溶剂挥发法制备了Phen-Fe3O4/PLA-PEG-PLA微球。通过傅里叶变换红外光谱(FT-IR)、核磁共振波谱(1 H-NMR)、X射线衍射(XRD)、扫描电子显微镜(SEM)对PLA-PEG-PLA及磁性微球的结构进行了表征分析。结果表明,微波法合成的PLA-PEG-PLA是一种三嵌段共聚物,载药微球呈规则球形,表面光滑,粒径分布较均匀。体外释放行为表明PLA-PEG-PLA作为载药基质具有明显的缓释性能。Phen-Fe3 O4/PLA-PEG-PLA-MS was prepared by emulsion-solvent evaporation method with PLA- PEG-PLA synthesized by microwave-assisted polymerization and nano-Fe3O4 synthesized by water-in-oil single microe- mulsion（one reactant） processing as drug carriers, 1,10-Phenanthroline（Phen）as model drug. The microstructure of PLA-PECrPLA and drug-loaded mierospheres were characterized and analyzed by FT-IR, l H-NMR , XRD and SEM. It was shown that PLA-PEG-PLA was of triblock copolymer. Microspheres were more regular and smooth. Its size distribution was uniformity. The study in vitro release behavior showed that PLA-PEG-PLA as a drug-loading matrix had obvious sustained-release property.

关 键 词：PLA-PEG-PLA 微波合成 邻菲罗啉 纳米四氧化三铁 载药微球 药物释放 

分 类 号：TB383[一般工业技术—材料科学与工程]