二氟尼柳胶囊溶出度的研究  

Study on the dissolution of diflunisal capsules

作　　者：林芳[1] 王胜浩[1] 韩锦文[1] 

机构地区：[1]浙江省医学科学院药物所,杭州310013

出　　处：《中国现代应用药学》2000年第2期117-119,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :通过对二氟尼柳胶囊溶出速率的评价 ,以期得到一个有较好溶出特性的胶囊剂。方法 :参照USP2 3版二氟尼柳片剂的溶出度测定方法 ,用紫外分光光度仪测定溶出度。结果 :二氟尼柳胶囊溶出度的方法回收率为1 0 0 .2 7% ,RSD为 0 .62 % ,重现性与均一性都较好。胶囊较原料的溶出度明显加快 ;与片剂相比 ,胶囊 5min时的溶出有一滞后时间 ,但T80 两者无显著差异 (胶囊T80 =1 2 .80min ,片剂T80 =1 3.0 4min)。结论 :二氟尼柳胶囊所选择的赋形剂能明显提高其溶出速率 ,胶囊与片剂均符合USP2OBJECTIVE:The dissolutions of diflunisal capsules were compared to find a product with good release properties.METHODS:Referring to the USP ⅩⅩⅢ,the dissolution of diflunisal capsule was determined by UV spectrophotometer and compared with those of both diflunisal material and its tablets(made by merck corporation).RESULTS:The dissolution of capsules had good repeatability.The average recovery was 100.27%(RSD=0.62%).The in vitro release of capsules was faster than those diflunisal material and available tablets.There were no significant differences between T 80 of capsules(12.80min) and that of tablet(13.04min).CONCLUSION:Compared with the imported tablets,the capsules formulated with CMS Na have a similar release matrix model and release rate.

关 键 词：二氟尼柳 胶囊 溶出度 消炎镇痛药 

分 类 号：R971.1[医药卫生—药品] R927.7[医药卫生—药学]