一种新的心肌声学造影技术:持续静脉滴注声振微泡的心肌声学造影方法研究  

Experimental Study of Myocardial Contrast Echocardiography by Continuous Injection of Sonicated Microbubbles:A Novel Methodological Research

作　　者：查道刚[1] 刘伊丽[1] 黄晓波[1] 罗义[1] 冯力[1] 谢志 宾建平[1] 陈树元[1] 金伟军[1] 

机构地区：[1]广州市第一军医大学南方医院心内科,510515

出　　处：《中国超声医学杂志》2000年第4期241-244,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金!(No.39870 32 9);国家新药研究基金!(No.96- 90 1 - 0 5- 88)的资助

摘　　要：目的 :探讨持续静脉滴注法行心肌声学造影的安全性及有效性。方法 :经犬外周静脉持续滴注微泡造影剂动态观察心肌显影效果及其对血流动力学的影响。结果 :2 ml/ min和 6 ml/ min滴注组分别于滴注后约 72 .7秒和19.9秒心肌开始显影 ,持续到滴注停止后约半分钟心肌显影消退。前降支套扎及再灌注过程中可观察到局部心肌声学造影充填、缺损、再充填的动态演变。全部造影过程中无血流动力学及心电图变化。结论 :持续静脉滴注法行心肌声学造影可安全有效地用于动态观察心肌血流灌注变化。Objective:To investigate the safety and efficacy of continuous injection of sonicated microbubbles for myocardial contrast echocardiography(MCE).Methods:To detect the contrast effect anf cardiac hemodynamics during continuous injection of contrast agent through femoral vein in 7 dogs.Results:Myocardial contrast effect appeared after 72 7 seconds and 19 9 seconds continuous injection at velocity of 2 ml/min and at 6 ml/min respectively.The contrast effect lasted about 30 sec.Contrast defect and reperfusion at LAD territory were demonstrated during LAD occlusion and release..No adverse effect with hemodynamics and ECG were found.Conclusion:MCE continuous infusion of sonicated microbubbles is a method of safety and efficacy for evaluating myocardial perfusion.

关 键 词：造影超声心动图 持续滴注法 心肌灌注 

分 类 号：R445.1[医药卫生—影像医学与核医学]