利多卡因减轻家兔心肌缺血-再灌注炎性损伤的研究  

The study of lidocaine on reducing inflammatory injury during myocardial ischemia/reperfusion injury in rats

作　　者：王友[1,2] 王保生[2] 林丽文[2] 林娜[2] 赵明耀[1] 

机构地区：[1]郑州大学基础医学院,河南郑州450052 [2]济宁医学院基础医学与法医学院,山东济宁272067

出　　处：《济宁医学院学报》2012年第2期100-102,共3页Journal of Jining Medical University

基　　金：济宁医学院2008年青年基金项目

摘　　要：目的研究利多卡因的抗炎作用对心肌缺血-再灌注损伤的保护作用。方法 18只家兔随机分为3组(每组6只),假手术组、缺血-再灌注组和利多卡因组。监测家兔左室内压峰值(LVSP)、±dp/dtmax,测定血浆IL-6的水平,光镜观察心肌损伤及中性粒细胞的浸润程度。结果与缺血-再灌注组比较,利多卡因组LVSP及±dp/dtmax再灌注后的恢复率均高于缺血-再灌注组(P<0.01),血浆IL-6浓度明显低于缺血-再灌注组(P<0.01),心肌损伤及中性粒细胞浸润程度较轻。结论利多卡因可以提高心功能,抑制炎症反应,减轻家兔心肌缺血-再灌注损伤。Objective To investigate the protective effects of lidocaine on myocardial ischemia/reperfusion injury.Methods Eighteen rabbits were randomly divided into 3 groups（n= 6 each）： sham-operated group,ischemia/reperfusion group and lidocaine group.Left ventricular systolic pressure（LVSP） and ±dp/dtmax of the heart were determined,and the level of plasma IL-6 was also measured.The degree of myocardial injury and neutrophils infiltration were observed with microscope.Results Compared with those of ischemia/reperfusion group,LVSP and ±dp/dtmax of the heart were better recovered during reperfusion in lidocaine groups（P0.01）.IL-6 concentration in plasma in lidocaine group were significantly lower than those in the ischemia/reperfusion group（P0.01） and the degree of myocardial injury and neutrophils infiltration were alleviated.Conclusion The results demonstrate that lidocaine could improve cardiac function,inhibit inflammatory response and attenuate reperfusion injury in ischemic heart.

关 键 词：利多卡因 心肌缺血 再灌注损伤 白介素-6 

分 类 号：R542.2[医药卫生—心血管疾病]