重组葡激酶溶栓作用的研究  

Effects of r-Sak on thrombolysis in rabbits and rats

作　　者：张艳[1] 李卫平[1] 明亮[1] 李京培[1] 徐叔云[1] 

机构地区：[1]安徽医科大学药理学教研室,合肥230032

出　　处：《中国药理学通报》2000年第2期187-189,共3页Chinese Pharmacological Bulletin

摘　　要：目的　研究重组葡激酶的溶栓作用。方法　通过测定家兔血浆优球蛋白溶解时间 (ELT)、纤维蛋白原降解产物(FDP)的含量及纤维蛋白原 (Fg)的含量 ,以观察重组葡激酶对家兔纤维溶解活性的影响。采用家兔动静脉旁路血栓形成法、家兔肺栓塞法及大鼠体外血栓形成法模型 ,以观察重组葡激酶的溶栓作用。结果　重组葡激酶 (6 2 5 0U·kg-1,1 2 5万U·kg-1)可明显缩短ELT ,增加FDP含量 ,对Fg含量无明显影响 ;重组葡激酶 (8333U·kg-1,2 5万U·kg-1,7 5万U·kg-1)在 3种血栓形成模型上 ,均有溶栓作用。结论　重组葡激酶具有明显的溶栓作用。AIM In this study, we observed the thrombolysis effect of r Sak in rabbits and rats. METHODS ELT, the content of FDP and Fg were assayed to study the effect of r Sak on activity of fibrinolysis. We observed the effect of r Sak on thrombolysis by three experimental models of thrombosis of artery vein circulation in rabbits and blocking in lung artery in rabbits and thrombosis of rats in vitro. RESULTS Compared with control, r Sak( 6 250 U·kg -1 , 12 500 U·kg -1 ) obviously lessened ELT and increased the content of FDP. Compared with control, r Sak( 8 333 U·kg -1 , 2 500 U·kg -1 and 7 500 U·kg -1 ) had the effect of thrombolysis in three experimental models of thrombosis. CONCLUSION r Sak had significant effect on thrombolysis.

关 键 词：重组葡激酶 溶栓作用 

分 类 号：R977.3[医药卫生—药品] R973.2[医药卫生—药学]