模拟胃环境中丝素蛋白复合材料的溶蚀机制  

Dissolution mechanism of composite materials consisting of SF,PVA and PEG in the simulated gastric juice

作　　者：陈忠敏[1] 张艳冬[1] 罗琴[1] 胡仁建[1] 

机构地区：[1]重庆理工大学药学与生物工程学院,重庆400054

出　　处：《丝绸》2012年第4期1-4,共4页Journal of Silk

基　　金：重庆市高等学校优秀人才支持计划(2011CQ04);国家教育部留学回国人员科研启动基金资助(2006CR01)

摘　　要：以聚乙二醇为增塑剂,通过水相共混法制备了不同比例的丝素蛋白/聚乙烯醇/聚乙二醇复合材料。利用红外光谱对复合材料进行了结构表征,并通过失重试验、红外光谱(FTIR)、X-射线衍射(XRD)、扫描电镜(SEM)对复合材料在模拟胃环境中的溶蚀机制进行了研究。结果表明,丝素蛋白/聚乙烯醇/聚乙二醇复合材料的溶蚀降解首先从丝素蛋白的溶出、分解,并形成细微孔道开始,然后胃液通过细微孔道逐步深入并溶蚀聚乙二醇和聚乙烯醇。该丝素蛋白/聚乙烯醇/聚乙二醇复合材料具有潜在的药物缓释应用前景。The composite materials consist of different ratios of silk fibroin （SF）, polyvinyl alcohol （PVA） and polyethylene glycol （PEG） which were prepared through the water phase blending method with polyethylene glycol as the plasticizer. The transformation of the composite materials before and after dissolution were investigated by the weight loss test, FTIR spectroscopy, scanning electron microscopy （SEM）, and X-ray diffraction （XRD）.The results reveal that the composite materials dissolve beginning with the digestion, decomposition of SF and formulation of micro-pores, and then the gastric juice dissolves PEG and PVA step by step through micro-pores. The composite materials are looked forward to using in the drug control-release system.

关 键 词：丝素蛋白 聚乙烯醇 聚乙二醇 药物缓释材料 溶蚀机制 

分 类 号：TS149[轻工技术与工程—纺织材料与纺织品设计]