Effect of intensive multifactorial treatment on the intima-media thickness of large arteries in patients with new-onset type 2 diabetes mellitus  

作　　者：Xiao-hong ZHAO Zhe-rong XU Qin ZHANG Hai-feng GU Yun-mei YANG 

机构地区：[1]Department of Geriatrics,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2012年第5期378-385,共8页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project(Nos.30700485 and 30771333)supported by the National Natural Science Foundation of China;the Zhejiang Provincial Natural Science Foundation of China(No.Y306641);the National Science & Technology Pillar Program in the Eleventh Five-Year Plan Period of China(No.2006BAI02B08)

摘　　要：Objective: To quantify the changes in blood glucose, blood lipids, blood pressure, and the intima-media thickness (IMT) of large arteries in patients with new-onset type 2 diabetes mellitus who received either intensive multifactorial treatment or conventional treatment. Methods: Two-hundred and ten patients with new-onset type 2 diabetes mellitus were randomly assigned to two groups: an intensive treatment group (n=110) and a conventional treatment group (n=100). Fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c), blood pressure, blood lipids [total cholesterol (TC), triglyceride (TG), low-density lipoprotein C (LDL-C), and high-density lipoprotein C (HDL-C)], and IMTs of large arteries (carotid, iliac, and femoral arteries) were determined before and at one and two years after starting treatment. The patients in the conventional treatment group received routine diabetes management in our outpatient department. Targets were established for patients in the intensive treatment group. Their blood glucose, blood lipids, and blood pressure levels were regularly monitored and therapeutic regimens were adjusted for those whose measurements did not meet the target values until all the parameters met the established targets. Within-group and between-group differences were evaluated. Results: A significantly greater percentage of patients in the intensive treatment group had LDL-C levels that reached the target value one year after starting treatment than those in the conventional treatment group (52.04% vs. 33.33%, P<0.05). No significant differences were found be- tween groups for FBG, HbA1c, blood pressure, TG, TC, or HDL-C. The percentages of patients with TG (51.02% vs. 34.48%), TC (52.04% vs. 33.33%), and LDL-C (61.22% vs. 43.67%) who met the respective target values in the in- tensive treatment group were all significantly higher than the corresponding percentages in the conventional treatment group two years after starting treatment (P<0.05). There were no significant differences in the percentages oObjective： To quantify the changes in blood glucose, blood lipids, blood pressure, and the intima-media thickness （IMT） of large arteries in patients with new-onset type 2 diabetes mellitus who received either intensive multifactorial treatment or conventional treatment. Methods： Two-hundred and ten patients with new-onset type 2 diabetes mellitus were randomly assigned to two groups： an intensive treatment group （n=110） and a conventional treatment group （n=100）. Fasting blood glucose （FBG）, glycosylated hemoglobin A1c （HbA1c）, blood pressure, blood lipids [total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein C （LDL-C）, and high-density lipoprotein C （HDL-C）], and IMTs of large arteries （carotid, iliac, and femoral arteries） were determined before and at one and two years after starting treatment. The patients in the conventional treatment group received routine diabetes management in our outpatient department. Targets were established for patients in the intensive treatment group. Their blood glucose, blood lipids, and blood pressure levels were regularly monitored and therapeutic regimens were adjusted for those whose measurements did not meet the target values until all the parameters met the established targets. Within-group and between-group differences were evaluated. Results： A significantly greater percentage of patients in the intensive treatment group had LDL-C levels that reached the target value one year after starting treatment than those in the conventional treatment group （52.04% vs. 33.33%, P〈0.05）. No significant differences were found be- tween groups for FBG, HbA1c, blood pressure, TG, TC, or HDL-C. The percentages of patients with TG （51.02% vs. 34.48%）, TC （52.04% vs. 33.33%）, and LDL-C （61.22% vs. 43.67%） who met the respective target values in the in- tensive treatment group were all significantly higher than the corresponding percentages in the conventional treatment group two years after starting treatment �

关 键 词：Type 2 diabetes mellitus Intensive treatment Intima-media thickness (IMT) Large arteries 

分 类 号：R587.1[医药卫生—内分泌]