白藜芦醇外涂对模拟日光照射所致皮肤红斑的抑制作用  

Inhibitive effects of topical resveratrol on skin erythema induced by solar simulator ultraviolet irradiation

作　　者：吴严[1] 贾丽丽[2] 郑颖娜[3] 高兴华[1] 陈洪铎[1] 李远宏[1] 

机构地区：[1]中国医科大学附属一院皮肤科,辽宁沈阳110001 [2]吉林大学附属第四医院皮肤科 [3]河南省人民医院皮肤科

出　　处：《中国美容医学》2012年第5期754-756,共3页Chinese Journal of Aesthetic Medicine

基　　金：2010年教育部高等学校博士学科点专项科研基金(课题编号:20102104120007)

摘　　要：目的:观察白藜芦醇外涂对模拟日光照射皮肤红斑的影响。方法:将20名志愿者左右侧背部分别划出6个部位。部位1～4分别涂抹白藜芦醇+抗氧化剂、抗氧化剂、白藜芦醇、基质,左侧先涂抹后照光,右侧先照光后涂抹;部位5、6分别为阳性及阴性对照。连续4天,观察皮肤红斑。结果:照光后第1、2天,部位1～3无或隐约可见淡红斑;第3、4天,部位1、3红斑较第2天无加深,部位2红斑加深但较部位5轻。左侧形成的红斑较右侧相应部位轻。结论:白藜芦醇外用可有效预防与治疗模拟日光照射诱导的皮肤红斑,尤以预防性应用效果更好。Objective To investigate the effect of topical resveratrol on skin erythema induced by solar simulator ultraviolet irradiation. Methods Twenty volunteers were recruited and 6 experimental sites were separately marked on their bilateral backs. Sites 1 to 4 were topically applied with resveratrol combination with antioxidant, antioxidant, resveratrol, base, respectively. The products were applied to left-side followed by irradiation, and the products were applied to right-side after irradiation. Sites 5 and site 6 were separatedly designated as positive control and negative control sites. The irradiation last 4 days and skin erythema was observed. Results On the 1st and 2nd days after irradiation, no or only slight erythema were observed on site 1 to site 3. On the 3rd and 4th days, the erythema of site 1 and site 3 remained unchanged comparing to that on the 2nd day, whereas the erythema of site 2 became obvious than before and lighter than that of site 5. The erythema on left-side is slighter than that on right-side. Conclusion Topical resveratol could effectively prevent （more obviously） and reverse the skin erythema induced by solar simulator ultraviolet irradiation.

关 键 词：白藜芦醇 紫外线 红斑 

分 类 号：R758[医药卫生—皮肤病学与性病学]