核因子κB及其SUMO化调控与糖尿病肺改变  

Sumoylation Control of NF-κB and Diabetic Lung Changes

作　　者：朱贺[1] 陈思娇[1] 宋金丹[2] 

机构地区：[1]中国医科大学附属第一医院干部工作医疗部老年医学研究室,沈阳110001 [2]中国医科大学附属第一医院医学分子生物学研究所卫生部细胞生物学重点实验室,沈阳110001

出　　处：《医学综述》2012年第8期1143-1146,共4页Medical Recapitulate

基　　金：辽宁省科技厅科学技术计划项目(2011225020)

摘　　要：核因子κB(NF-κB)是一种广泛存在于机体各种细胞中的核转录因子,受到外界刺激时可被激活进入细胞核参与炎性反应。小泛素相关修饰物(SUMO)广泛存在于真核细胞中,包括SUMO1、SUMO2、SUMO3和SUMO4 4个成员。SUMO可以与靶蛋白(如IκB)结合,对其进行SUMO化修饰,间接调控NF-κB转录。近年来研究发现,NF-κB在糖尿病及其并发症的发生、发展中起着重要作用。现就NF-κB的结构,信号通路及其调控以及与糖尿病肺脏改变的关系进行综述。The nuclear factor kappa B（NF-κB）is a kind of nuclear transcription factor,which exists in various of cells widely.When it is stimulated by the external world,it will get into nucleus to participate in inflammation.The small ubiquitin-related modifier（SUMO）exists in eukaryotic cells widely,which has four members：SUMO1,SUMO2,SUMO3 and SUMO4.SUMO can bond with the target protein,and make it sumoylation,indirectly control the transcription of NF-κB.According to the recent studies,NF-κB plays a significant role in the development of the diabetes and its complications.Here is to make a review on the structure and the signal pathway of NF-κB,and the control of NF-κB,and its correlations with the diabetic lung changes.

关 键 词：核因子ΚB 小泛素样修饰蛋白化 糖尿病 肺脏 

分 类 号：R587.1[医药卫生—内分泌]