维生素D受体FokⅠ基因多态性与内蒙古地区蒙汉人群糖尿病肾病的相关性研究  

Correlation between Vitamin D Receptor FokⅠ Gene Polymorphisms and Diabetes Nephropathy in Mongolian and Han Population in Inner Mongolia Region

作　　者：常永丽[1] 

机构地区：[1]内蒙古医学院附属医院肾内科,呼和浩特010050

出　　处：《医学综述》2012年第8期1243-1245,共3页Medical Recapitulate

摘　　要：目的探讨维生素D受体基因FokⅠ酶切位点多态性与内蒙古蒙汉人群糖尿病肾病之间的关系。方法选择2008年6月至2010年8月在内蒙古医学院附属医院肾内科及内分泌科住院的糖尿病肾病(DN)患者287例,其中蒙古族患者117例,汉族患者170例。分别采静脉血1 mL,运用聚合酶链反应-限制性酶切片段长度多态性分析方法测定所有患者维生素D受体FokⅠ基因多态性等位基因频率和基因型频率。结果全部研究对象中共见FF、ff、Ff三种基因型。蒙古族糖尿病肾病患者FF基因型频率为37.8%、ff基因型频率为22.2%,Ff基因型频率为40%,而汉族糖尿病肾病患者的频率分别为55.1%、9%和35.9%。结论内蒙古地区蒙古族与汉族的糖尿病肾病与VDR基因FokⅠ多态性有关联性;F等位基因可能是内蒙古地区蒙古族糖尿病肾病的易感因素。Objective To investigate whether vitamin D receptor（VDR） gene FokⅠ polymorphism is associated with diabetic nephropathy（DN） in Mongolian and Han population in Inner Mongolia region.Methods A total of 287 patients,117 Mongolian and 170 Han admitted in nephrology department and endocrinology department of Inner Mongolia Medical College Affiliated Hospital from June 2008 to August 2010 of department were included.1 mL of venous blood was collected respectively,using the polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） analysis method was used for the determination of vitamin D receptor FokⅠ gene polymorphism allele frequency and genotype frequency.Results The genotype frequencies for FF,ff and Ff were 37.8%,22.2% and 40% in the Mongolian DN group;and 55.1%,9% and 35.9% respectively in the Mongolian normal control group.Conclusion ①This study showed that VDR gene FokⅠ polymorphism is associated with diabetic nephropathy of Mongolian population and Han populationin Inner Mongolia area.②The F allele may be the predisposing factor of diabetic nephropathy of Mongolian population in Inner Mongolia area.

关 键 词：糖尿病肾病 维生素D受体 FokⅠ 基因多态性 PCR-RFLP 

分 类 号：R587.1[医药卫生—内分泌]