双氯芬酸钠利多卡因和哌替啶治疗肾绞痛的对比研究  

Compaison between Diclofanac odium lidocaine Hydrochloride and Pethidine with anisodamine in treating acute renal colic

作　　者：陈小林[1] 杨大金[1] 曾平海[1] 

机构地区：[1]解放军第一七四医院急诊外科,厦门361003

出　　处：《中国实用医药》2012年第9期16-17,共2页China Practical Medicine

摘　　要：目的观察并比较双氯芬酸钠利多卡因和哌替啶各联合山莨菪碱治疗肾绞痛的疗效及安全性。方法 280例肾绞痛患者随机分为观察组和对照组各140例,观察组:一次性同时肌内注射双氯芬酸钠利多卡因2ml(含双氯芬酸钠75mg,利多卡因20mg)和山莨菪碱10mg;对照组一次性同时肌内注射哌替啶75mg和山莨菪碱10mg。观察比较两种方法给药后1h内的镇痛效果及不良反应。结果两组的镇痛效果无明显差异(P>0.05),但不良反应比较差异具有统计学意义(P<0.01)。结论双氯芬酸钠利多卡因与哌替啶用于肾绞痛疗效相似,但不良反应少,无成瘾性,临床应用方便,值得推广。Objective To compare the effiicacy and safety of the Diclofanac odium Lidocaine Hydrochloride for injection and Pethidine with anisodamine in treating acute renal colic in the treatment of acute renal colic.Methods 280 patients with acute renal colic were randomized into two groups：the study group treated with Diclofanac odium Lidocaine Hydrochloride for injection,2 ml,im.（Diclofanac sodium 75 mg,Lidocaine 20 mg）,and anisodamine 10 mg,im.The control group treated with Pethidine 75 mg,im.and anisodamine 10 mg,im.The intensity change of renal colic and adverse reactions were described during 1 h from the beginning of propacetamol infusion.Results There was no obvious difference between the two groups on moderating renal colic（P〈0.05）.The incidence of side effects form Propacetamol HCL was less Pethidine HCL（P〈0.01）.Conclusion Intravenous Diclofanac odium Lidocaine Hydrochloride and Intramuscuiar Pethidine HCL had the similar efficacy in treating acute renal colic.Since Diclofanac odium Lidocaine Hydrochloride had less adverse reactions,it will more applicated as analgesic in the future.

关 键 词：双氯芬酸钠利多卡因 哌替啶 山莨菪碱 肾绞痛 

分 类 号：R691[医药卫生—泌尿科学]