自组装多肽支架材料的研究进展  

Research Advances in Self-assembling Peptide Scaffolds

作　　者：王韵晴[1] 卢婷利[1] 陈婷[1] 马玉樊[1] 赵雯[1] 陈涛[1] 

机构地区：[1]西北工业大学生命学院,空间环境模拟技术国防重点学科实验室,陕西西安710072

出　　处：《材料科学与工程学报》2012年第2期324-328,311,共6页Journal of Materials Science and Engineering

基　　金：国家自然科学基金资助项目(20872119);陕西省自然科学基金资助项目(2010JM2021)

摘　　要：多肽分子可以利用氢键、疏水性作用、π-π堆积作用等非共价键力自组装形成形态与结构特异的多肽分子聚集体,如分子积木、分子开关、分子涂料及纳米纤维等,由于多肽分子良好的生物相容性和可调控的降解性,自组装多肽在组织工程、药物缓释等方面表现出巨大的应用潜力。本文总体介绍了多肽自组装的几种结构模型及自组装的设计原则,重点叙述了自组装多肽作为组织工程支架材料的研究进展。Peptide can self assemble through the noncovalent bond action,such as hydrogen bond,hydrophobicity and π-π accumulation,and form different peptide molecular aggregations,for example,molecular brick,molecular switch,molecular paint and nanofiber.These self-assembling peptides are characterized by their good biocompatibility and regulatory biodegradation.So it is a potential biomaterial in the field of tissue engineering and sustained drug delivery systems.In this paper,we describe several structure models made from self-assembling peptides and the general principles for peptide designs.The research of self-assembling peptide scaffolds in tissue engineering is described in detail.

关 键 词：自组装多肽 纳米纤维 组织工程 支架材料 

分 类 号：Q819[生物学—生物工程]