心肌肌钙蛋白T在急性心肌梗死及冠脉内溶栓中的应用价值  

Application value of Cardiac troponin T in acute myocardial infarction and thrombolytic therapy within coronary artery

作　　者：徐任璇 戎顺水 毕瑛 杨丽萍 朱志远 

机构地区：[1]上海市杨浦区安图医院心内科,200093

出　　处：《中国综合临床》2000年第4期258-259,共2页Clinical Medicine of China

摘　　要：目的探讨心肌肌钙蛋白T（CTnT）在急性心肌梗死（AMI）及冠脉内溶栓中的应用价值。方法采用酶联免疫分析法，进行动态检测。结果AMI患者发病3小时内CTnT阳性率71％，最大峰值为正常临界值的31倍，持续时间可达2～3周。溶栓后完全再通者CTnT呈双峰样变化，12小时与72小时峰值＞1，第1酶峰提前在发病后12小时出现。不完全再通及未溶栓者CTnT虽呈双峰样变化，但20小时与72小时峰值比＜1。结论CTnT是一项高灵敏度、高特异性、能够在极早期和亚急期诊断AMI，同时还可判断溶栓后相关血管是否完全再通的检测指标。Objective To study the application value of Cardiac troponin T(CTnT) in acute myocardial infarction (AMI) and thrombolytic therapy within coronary artery. Methods Dynamic monitoring was carried out by means of enzyme linked immunoassay. Results The positive rate of CTnT in patients with AMI was 71 % in 3h after attack. The maximum peak of CTnT was 31 times higher than the normal clinical value,and it might continue 2~3 weeks. When coronary artery gained a full reperfusion after thrombolitic therapy,CTnT showed a biphasic curve. The peak ratio at 12 h and 72 h was more than 1,and the first peak of enzyme appeared as early as within 12 h after attack. Although CTnT showed a biphasic curve in patients who neither gained full reperfusi0n nor receiving thrombolytic therapy,their ratio of peak at 20 h and 72 h was less than 1. Conclusion CTnT is a sensitive and specfic monitoring index,which can be used to diagnose AMl in most early and subacute stage and to judge whether blood vessels concernedhave gained full reper fusion after throblytic therapy.

关 键 词：急性 心肌梗死 心肌肌钙蛋白T 溶栓疗法 

分 类 号：R542.22[医药卫生—心血管疾病]