聚-α、β-(3-羟丙基)-DL-天冬酰胺键合左旋18-甲基炔诺酮的合成、表征及体外释放  

Synthesis, Characterization and in Vitro Release of Levonorgestrel Coupled to a Biocompatible Material:Poly-α,β-(3-hydroxypropyl)-DL-Aspartamide

作　　者：邹韵[1] 汤谷平 

机构地区：[1]浙江医科大学附属妇产科医院,杭州310006 [2]浙江医科大学药学院药物分析教研室,杭州310006

出　　处：《生殖与避孕》2000年第2期79-82,共4页Reproduction and Contraception

基　　金：国家自然科学基金资助项目!(39570219)

摘　　要：具有临床意义的甾体类避孕药左旋 1 8甲基炔诺酮 (L NG)键合于生物相容性聚氨基酸材料 :α、β 聚 (3羟丙基 ) DL 天冬酰胺上 ,制成长效控释药物。用红外光谱法、差热分析等分别对材料及键合药物进行了表征 ,药物的接入率达 2 7.0 % (w/ w) (n=3) ,共价缩合物以棒状形式释药进行了体外水解和酶解释放试验。结果表明 。Contraceptive levonorgestrel (LNG) was coupled to polyα、β(3hydroxypropyl)DLaspartamide,a biodegradable and biocompatible material.The drug loaded in the polymer was about 27.0% (w/w). The polymer conjugate was characterized by differential scanning calorimertry (DSC) and fourier transform infrared (FTIR). The in vitro release of levonorgestrel from the biocompatible polymer conjugate was studied in TrisHCl (0.1 mol/L) and trypsin. Levonorgertrel was measured by HPLC. The data indicate that this levonorgestrel polymer conjugate can be released in these two systems but faster in trypsin.$$$$

关 键 词：甲基炔诺酮 聚天冬酰胺 LNG 体外释放 

分 类 号：R979.21[医药卫生—药品]