利洛司酮抗着床效应及其对子宫内膜前列腺素含量的影响  

The Anti-implantation of Lilopristone(ZK98734) and its Effects on the Contents of Endometria PGs in Rat

作　　者：王晶磊[1] 奚明[1] 杨明 杨丽珍 谢衷明 

机构地区：[1]江西医学院,南昌330006 [2]上海计划生育科学研究所,上海200032

出　　处：《生殖与避孕》2000年第2期83-86,共4页Reproduction and Contraception

摘　　要：本文观察抗孕激素利洛司酮 (lilopristone ZK98734)对大鼠着床、子宫内膜 PGs含量及血浆孕酮含量的影响。结果显示 :(1 ) 5 mg/ kg ZK98734可明显抑制胚泡着床 (对照组着床率 72 .5 0± 5 .6 8% ;ZK98734组 43.30± 3.86 % ) ;(2 ) ZK98734可促使子宫内膜内源性PGE2 和 PGF2α含量增加 ,5 mg/ kg、1 6 .5 mg/ kg和 2 5 mg/ kg三种剂量呈正相关剂量效应关系 ;(3) ZK98734明显降低血浆孕酮水平 ,三种剂量呈负相关剂量效应关系。提示 :ZK98734可能通过改变着床前子宫孕酮和前列腺素之间的精细平衡 ,干扰着床前子宫“静态”的生理环境 ,不利于胚泡在子宫内附着和发育 。This study was undertaken in adult female rats to investigate the effects of ZK98734 on inhibition of blastocyst implantation, the contents of prostaglandins(PGs) in endometria tissue and the plasma concentration of progesterone. The results show that: (1) ZK98734 (5 mg/kg) could obviously inhibit blastocyst implantation (the control group 72.50±5.68%, the ZK98734 group 43.30±3.86%, P<0.01). (2) ZK98734 significantly increased the endometrial endogenous PGE 2 and PGF 2α production, and there is a positive doseeffect relationship among these three dosages (5 mg/kg, 16.5 mg/kg and 25 mg/kg). (3) ZK98734 significantly decreased the plasma progesterome concentration. There is a negative doseeffect relationship among these three dosages. The results suggested that ZK98734 might play antiimplantation effect by changing the ratio between uterine progesterone and prostaglandins in preimplantation.

关 键 词：利洛司酮 抗着床率 孕酮 子宫内膜 前列腺素 

分 类 号：R979.21[医药卫生—药品]