因月经异常停用国产皮下埋植剂的影响因素分析  

Risk Factors for Discontinuation of 2 Types of Domestic Levonorgestrel Subdermal Implants due to Menstrual Irregularities

作　　者：薛丽[1] 方可娟[1] 高尔生[1] 范慧民[2] 关艳敏 

机构地区：[1]上海市计划生育科学研究所,上海200032 [2]北京妇产医院,北京100006 [3]辽宁省计划生育研究院,沈阳110037

出　　处：《生殖与避孕》2000年第2期98-104,共7页Reproduction and Contraception

摘　　要：本文采用国家“八·五”科技攻关项目“国产皮下埋植避孕方法多中心研究 (扩大应用 )”资料 ,分析中国妇女使用国产皮下埋植剂后因月经异常停用的影响因素。月经异常是皮下埋植剂最主要的停用原因 ,二年末因月经异常的累积停用率 I 型和 II 型分别为8.96 %和 7.84%。采用 COX多元逐步回归分析因月经异常停用的影响因素。结果表明 :文化程度高、产次低者因闭经停用的风险率较高 ,农民较其它职业者因闭经停用的风险率低 ,I型埋植剂因闭经停用的风险率高于 II型 ;文化程度高、体重轻、埋植时不哺乳、产次低、末次避孕方法使用 IUD或屏障法者因“其它”月经异常 (指除闭经以外的其它月经异常 )停用的风险率较高。农民较其它职业者因“其它”月经异常停用的风险率低 ;不同地区的妇女因月经异常停用的风险率不同。本研究结果提示 :应在手术前有针对性地做好咨询服务工作 。Data from the national key research 'A multicentre study of 2 types of domestic levonorgestrel subdermal implants (expanded application)' were analyzed to study the factors that may be associated with discontinuation of two types of levonorgestrel subdermal implants(type I and type II) due to menstrual irregularities among Chinese users. Menstrual irregularities were the predominant reasons for discontinuation of implant using. At the end of year 2, the gross cumulative life table discontinuation rates for menstrual irregularities were 8.96 per 100 women (type I) and 7.84 per 100 women (type II). The results of stepwise COX regression showed that women were more likely to discontinue implant using due to amenorrhea if they had a higher education level and lower parity; farmers were less likely to request removal for amenorrhea; type I users were more likely to discontinue implant using due to amenorrhea than type II users. Women were more likely to discontinue implant using due to menstrual irregularities other than amenorrhea if they had a higher education level, had lighter body weight, were not breastfeeding at the time of insertion, had lower parity, had used IUDs or barrier methods as contraceptive before implant insertion; farmers were less likely to request removal for menstrual irregularities other than amenorrhea. Regional factor strongly affect women's discontinuation of implant use due to menstrual irregularities. Identifying these potential risk factors may help providers to counsel and guide women to accept implant method.$$$$

关 键 词：皮下埋植剂 月经异常 停用 COX模型 

分 类 号：R979.21[医药卫生—药品]