愈心痛胶囊联合开搏通防治急性心肌梗死缺血再灌注损伤疗效观察  

An observation of therapeutic effects of Yuxintong capsule combined with capoten on the ischemic-reperfusion injure second to acute myocardial infarction

作　　者：马桂兰[1] 朱士达 阚建英[1] 张俊萝 陈哲新 

机构地区：[1]天津市第二医院,300141

出　　处：《河北中医》2000年第4期291-293,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的　观察愈心痛胶囊联合开搏通对急性心肌梗死 (AMI)缺血再灌注损伤的防治作用。方法　 94例 AMI分 3组 ,全部病例均首先予溶栓治疗。在缺血再灌注损伤防治中 ,对照组(A组 )采用 AMI常规治疗 ;开搏通组 (B组 )在 A组治疗基础上加服开搏通 1 2 .5mg,每日 2次 ;愈心痛组 (C组 )在 B组基础上加服愈心痛胶囊 3粒 ,每日 3次。比较 3组溶栓后 4h内再灌注心律失常及治疗后 1周内心血管事件发生情况。检测溶栓后不同时间血浆内皮素 (ET)、丙二醛 (MDA)水平。结果　C组溶栓后 4h加速性室性自搏律 (AIVR)、阵发性室性心动过速 (VT)发生率显著低于A组 (P <0 .0 5) ;近期发生的心血管事件极显著低于 A组 (P <0 .0 1 ) ,也显著低于 B组 (P <0 .0 5) ;C组溶栓后 2 4 h及 72 h血浆 ET及 MDA极显著低于 A组 (P <0 .0 1 ) ,也显著低于 B组 (P<0 .0 5)。结论　愈心痛胶囊对 AMI缺血再灌注损伤有防治作用 。Objective To evaluate the protective effect of Yuxintong capsule combinated with capoten on injure of ischemic-reperfusion.Methods 94 patients with AMI were allocated to three groups and treated by thrombolysis. In A group (n=30) routine therapy of AMI was utilized and in B group (n=33) routine therapy of AMI combined with capoten was used, and in C group combination of routine method and capoten and Yuxintong capsule was investigate. Level of plasma endothelin(ET) and malonic dialdehyde(MDA) in different duration were tested. Results Level of ET and MDA in C group are the lowest and those in A group are the highest. The incidences of AIVR, VT in C group were also the lowest.Conclusions The protective effect of Yuxintong capsule combinated with capoten on injure of ischemicreperfusion second to acute myocardial infarction is definite.

关 键 词：急性心肌梗死 缺血再灌注损伤 愈心痛胶囊 

分 类 号：R259.422.2[医药卫生—中西医结合] R542.220.5[医药卫生—中医内科学]