冷腹膜透析液腹腔灌洗抢救热射病休克的实验研究  

Experimental study on emergency treatment with cool peritoneal dialysis solution lavage in heatstroke shock model

作　　者：张水文[1] 覃敏 杨军[2] 华旭初[2] 邹飞[2] 张枫桐[2] 

机构地区：[1]北京军区总医院皮肤科变态反应室,100710 [2]第一军医大学

出　　处：《中华劳动卫生职业病杂志》2000年第2期91-93,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：全军"九五"指令性课题

摘　　要：目的　探讨热射病休克的抢救方法。方法　将家兔热暴露至休克 ,再将其置于室温下。用传统的冷水浸泡和冷腹膜透析液 (PDS)腹腔灌洗方法抢救 ,观察动物中心体温的变化和存活时间 ,以及血液中K+ 浓度、pH值的变化。结果　冷水浸泡组 (n =8)直肠温度 (Tr)和食道温度 (Te)下降缓慢 ,平均存活 (16 .3± 2 5 .2 )min。冷PDS腹腔灌洗组 (n =10 )平均存活 (98.5± 6 7.4)min ,Tr和Te下降迅速 ,血压回升 ,比冷水浸泡组存活时间显著延长 ,休克时血K+ 浓度升高、酸中毒明显 ,透析后 30min得以改善。结论　冷PDS腹腔灌洗是抢救热射病休克有效的方法 ,为进一步救治赢得了时间。Objective To investigate the rescue method of shock in heatstroke.Methods Rabbits were exposed to hot environment until heat shock ensued and then they were laid under room temperature.The changes of body core temperature,survival time,K + concentration and pH of the arterial blood following different rescue measures were observed.Results In cold water immersion group( n =8),the rectal temperature( T r) and esophageal temperature( T e) decreased slowly,and the mean survival time was (16.3±25.2)min.In cool peritoneal dialysis solution(PDS) lavage group( n =10), T e and T r decreased promptly and arterial blood pressure increased.K + concentration and pH of the arterial blood after lavage improved significantly.The mean survival time was prolonged to (98.5±67.4)min.Conclusion PDS peritoneal lavage cooling is an effective measure to rescue from shock in heatstroke and is able to win one golden hour for the further treatment of heatstroke.

关 键 词：热射病 休克 腹腔灌洗 腹膜透析液 

分 类 号：R459.5[医药卫生—治疗学]