镁剂治疗对急性心肌梗死患者预后的影响  

Effects of Magnesium Therapy on Prognosis of Patients with Acute Myocardial Infarction

作　　者：夏大胜[1] 刘书坤[1] 郭倩玉[1] 贾国英[1] 高陆[1] 于翔[1] 

机构地区：[1]天津市第一中心医院心内科,300192

出　　处：《天津医药》2000年第4期212-214,共3页Tianjin Medical Journal

摘　　要：目的:评价静脉镁剂治疗对急性心肌梗死(AMI)患者预后的影响。方法:将80例溶栓的AMI患者随机分为治疗组(40例)和对照组(40例)。两组常规治疗相同,唯治疗组另给予门冬氨酸钾镁静滴治疗。两组均在梗死后3周进行超声声学定量检测左心功能。结果:治疗组再灌注心律失常发生率为52.5%,低于对照组的82.5%(P<0.01)。治疗组急性期室早、室速及室颤分别为47.5%、12.5%和2.5%,均低于对照组72.5%、32.5%和20%(均P<0.05)。治疗组4周内的梗死后心绞痛、再梗死、心力衰竭和病死率分别为7.5%、0、20%和2.5%,均低于对照组的27.5%、15%、37.5%和17.5%(均P<0.05)。治疗组EDV、ESV和TPFR均显著低于对照组(均P<0.01),而EF、PER和PFR均高于对照组(均P<0.01)。结论:静脉镁剂治疗能减少AMI患者近期心脏事件,改善病人的预后。Objective:To evaluate the effects of intravenous magnesium therapy on the prognosis of patients with acute myocardial infarction (AMI). Method:80 patients with AMI being eligible for thrombolysis were randomly assigned into treatment group (40 cases) and control group (40 cases). The control group was treated with conventional therapy. The treatment group received conventional therapy and intravenous infusion of potassium-magnesium aspartate. Left ventricular function of all the patients was measured using acoustic quantification (AQ) technology at 3 weeks after myocardial infarction. Results: The incidence of reperfusion arrhythmias in treatment group was obviously less than control group (52.5% vs 82.5% ,P< 0.01). The rate of ventricular premature beats, ventricular tachycardia and fibrillation within acute phase in treatment group were significantly decreased in comparing with control group (47.5% vs 72.5% , 12.5% vs32.5%,2.5% vs 20%,re-spectively, all P<0.05).The prevalence of post-infarction angina pectoris,reinfarction,heart failure and mortality within four weeks in treatment group were markedly reduced as compared with control group (7.5% vs27.5%,0 vs15%,20% vs 37.5% ,2.5% vs 17.5% ,respectively,all P<0.05).EDV,ESV and TPFR in treatment group were remarkably lower than control group (all P<0.01), whereas EF,PER and PFR in treatment group were significantly higher than control group (all P<0.01). Conclusion:Intravenous magnesium therapy could reduce cardiac events of patients with AMI in short term,and improve prognosis of patients.

关 键 词：急性 心肌梗死 镁剂 治疗 预后 

分 类 号：R542.22[医药卫生—心血管疾病]