槲皮素对博莱霉素致鼠肺纤维化的防治作用  

The protective effects of quercetin on Bleomycin-Induced pulmonary fibrosis in rats

作　　者：王昌明[1] 黄慧[1] 张珍祥[1] 莫碧文[1] 白晶[1] 曾锦荣[1] 蒋述科[1] 任格 王绩英[1] 

机构地区：[1]广西桂林医学院附属医院呼吸内科,桂林541001

出　　处：《中国药理学通报》2000年第1期94-96,共3页Chinese Pharmacological Bulletin

基　　金：广西壮族自治区卫生厅青年基金课题!NoQ9802

摘　　要：目的　观察SD大白鼠腹腔内注射槲皮素 ( 2 0 0mg·kg-1)对实验性博莱霉素致肺纤维化的防治作用。方法　通过博莱霉素 ( 5mg·kg-1)致鼠肺纤维化的动物模型 ,动态观察各实验组与肺纤维化形成相关的d 3、d 7、d 14、d 2 8肺组织匀浆内羟脯氨酸、脂质过氧化物 (LPO)含量 ,动态观察肺组织病理学变化及形态学定量测量肺组织中炎症组织数 /每高倍视野、肺泡间隔宽度、单位面积肺纤维化灶所占的分面积。结果　与对照组相比 ,槲皮素组能显著地降低博莱霉素致肺纤维化程度。AIM To explore the possible effects of querctin (200 mg·kg -1 , ip) on bleomycininduced pulmonary fibrosis in rats METHODS The model for pulmonary fibrosis in rats was established by intratracheal administration of BLM (5 mg·kg -1 ) The amount of lipidperoxides (LPO), hydroxyproline in lung issuse hemogenate was determined at 3, 7, 14, 28 day after Bleomycin administration respectively In addition, histological changes, width of alveolar septa, and percentage areas of pulmonary fibrosis scars were measured RESULTS The amounts of LPO, hydroxyproline of lung homogenate were significantly decreased, and BLMinduced pulmonary damage was ameliorated by quercetin CONCLUSION Quercetin can prevent from BLMinduced pulmonary fibrosis in rats

关 键 词：博莱霉素 槲皮素 肺纤维化 防治 

分 类 号：R563.13[医药卫生—呼吸系统] R974[医药卫生—内科学]