老年人慢性HBV感染的临床特点分析  

Clinical characteristics analysis on chronic hepatitis B virus infection in the aged patients

作　　者：李勇年[1] 刘淮阳[1] 吴炜强[1] 翟佩任[1] 燕青松[1] 魏丽军[1] 高建兴[1] 连建奇[2] 

机构地区：[1]解放军第323医院感染科,西安710054 [2]第四军医大学唐都医院传染病科,西安710038

出　　处：《中国肝脏病杂志（电子版）》2012年第1期10-12,共3页Chinese Journal of Liver Diseases：Electronic Version

基　　金：国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2008ZX10002-006)

摘　　要：目的探讨老年人慢性乙型肝炎病毒(HBV)感染的疾病谱及临床特点。方法比较53例老年慢性HBV感染者与相同例数的低年龄组慢性HBV感染者的性别、疾病谱、血清HBVDNA和ALT水平。结果老年组慢性HBV感染的疾病谱与低年龄组有显著不同,前者以非活动性HBsAg携带者为主(66.0%),后者中HBeAg阳性慢性乙型肝炎患者较多(47.2%)。老年组慢性HBV感染者血清HBVDNA和ALT均明显低于低年龄组,差异有统计学意义(P<0.05或P<0.01)。两组总体性别组成差异无统计学意义。结论非活动性HBsAg携带者是老年慢性HBV感染的主要疾病谱,但HBeAg阳性或阴性慢性乙型肝炎(CHB)和乙型肝炎肝硬化的发生率仍较高,且存在HBV复制和肝脏病变。Objective To explore the clinical characteristics of chronic hepatitis B virus （HBV） infection in the aged. Methods Total of 53 cases with chronic HBV infection in the aged （ 60 years） were compared with 53 younger cases （13-58 years old, mean age 30.9 years） in gender, disease spectrum, serum level of HBV DNA and alanine aminotransferanse （ALT）. Results Among the older cases, 35 cases （66.0%） are inactive HBsAg carrier, six （11.3%） are chronic hepatitis B patients with HBeAg positive, five （9.4%） are chronic hepatitis B patients with HBeAg negative, seven （13.2%） are cirrhosis related to chronic hepatitis B, with a greatly different disease spectrum of those in younger cases with chronic HBV infection （P 0.01）. The average serum HBV DNA （6.94 ± 5.92） × 106 copies/ml and ALT （30.8 ± 16.5） U/L in old cases are obviously lower than that in younger cases, （1.54 ± 1.21） × 107 copies/ml and （83.8 ± 62.5） U/L respectively. There is no obviously gender difference between the older and younger cases. Conclusions Four common chronic hepatitis B were observed in the cases with chronic HBV infection in the aged but active HBsAg carrier accounted for majority of disease spectrums. HBV replication and liver histological inflammation do in older patients with chronic HBV infection, especially in those with HBeAg positive or negativeand chroinc hepatitis B and cirrhosis.

关 键 词：肝炎 乙型 慢性 肝炎病毒 乙型 肝硬化 老年人 

分 类 号：R512.62[医药卫生—内科学]