pH响应的介孔二氧化硅纳米颗粒的制备及可控释放  

Preparation of a pH-Responsive Carrier Based on Mesoporous Silica Nanoparticles and Its Application for Controlled Release

作　　者：曹杰[1,2,3] 何定庚[1,2,3] 何晓晓[1,4,3] 王柯敏[1,4,2,3] 赵应香[1,2,3] 

机构地区：[1]湖南大学化学生物传感与计量学国家重点实验室,长沙410082 [2]湖南大学化学化工学院,长沙410082 [3]湖南大学生物纳米与分子工程湖南省重点实验室,长沙410082 [4]湖南大学生物学院,长沙410082

出　　处：《高等学校化学学报》2012年第5期914-918,共5页Chemical Journal of Chinese Universities

基　　金：国家科技部国际合作专项(批准号:2010DFB30300);湖南省自然科学基金创新研究群体(批准号:10JJ7002);湖南省科技计划项目(批准号:2011FJ2001);国家自然科学基金(批准号:90606003,20775021,91027000)资助

摘　　要：选择带负电荷且溶解度和分子结构对pH值非常敏感的聚丙烯酸作为封堵分子,采用静电吸附的修饰方法,制备了pH响应的MCM-41型介孔二氧化硅纳米颗粒.利用高倍透射电子显微镜(TEM)、X射线衍射(XRD)、傅里叶变换红外光谱(FTIR)及比表面积分析等手段表征了介孔二氧化硅纳米颗粒的物理化学性质.以联钌吡啶染料分子作为模式客体分子,研究了pH调控下的模式客体分子在介孔二氧化硅纳米颗粒中的包裹及释放行为.结果表明,该介孔二氧化硅纳米颗粒对pH具有很好的响应性;在近中性条件下,带正电的二氧化硅纳米颗粒通过静电吸附作用吸附带负电的聚丙烯酸,导致介孔封堵,使包载的染料分子几乎无释放;客体分子的释放率随着pH值的降低而升高,当pH≤5时,染料分子显著释放,pH=1时客体分子的释放率高达98%,可以实现对包载客体分子的控制释放.该pH响应的介孔二氧化硅纳米颗粒载体具有制备简便、价格低廉和包载量大等优点,有望应用于药物的控制释放.A pH-responsive carrier was prepared by electrostatic interaction between positively charged mesoporous silica nanoparticles and negatively charged poly（acrylic acid）.The physical and chemical properties of the as-synthesized mesoporous silica nanoparticles were characterized by transmission electron microscopy（TEM）,X-ray diffraction assay（XRD）,Fourier transform infrared spectroscopy（FTIR）,Brunauer-Emmett-Teller（BET） and Barrett-Joyner-Halenda（BJH） analyses.Loading efficiency and controlled release properties of the carrier were investigated with [Ru（bipy） 3]Cl 2 dyes as guest molecules.It was demonstrated that the mesoporous silica nanoparticles carrier was very sensitive to pH and exhibited good property of pH-responsive release.At neutral pH,positively charged nanoparticles interacted with negatively charged poly（acrylic acid） by electrostatic adsorption,resulting in the closing of the mesopores.The dyes could hardly be released from the nanoparticles.When the pH value was decreased,the percentage release of dye molecules increased.The dye was released sharply when the pH value was lower than 5.Cumulative release of the dye reached to 98% at pH=1.0,280 min.These results demonstrated that the release of the guest molecules could be controlled by pH adjustment.This new type of pH-responsive controlled release system based on mesoporous silica nanoparticles has the advantages of simply synthesis,low cost,and large load capacity,which made it have potential application in drug controlled release.

关 键 词：介孔二氧化硅纳米颗粒 控制释放 聚丙烯酸 pH响应载体 

分 类 号：O657[理学—分析化学]