不同方法制备枸杞籽油微乳的比较研究  

Comparison of the Preparation Methods of Boxthorn Seed Oil Microemulsion

作　　者：刘晨[1] 王文苹[2,3,4] 戴贵东[2,3,4] 

机构地区：[1]宁夏医科大学总医院,银川750004 [2]宁夏医科大学药学院,银川750004 [3]宁夏回药现代化工程技术研究中心,银川750004 [4]宁夏医科大学宁夏医药研究所,银川750004

出　　处：《中国药房》2012年第19期1749-1752,共4页China Pharmacy

基　　金：国家科技支撑计划项目(2009BAI72B03)

摘　　要：目的:优选枸杞籽油微乳的处方组成,比较枸杞籽油微乳的3种制备方法。方法:以枸杞籽油自身作为油相,利用外观、乳滴粒径、三元相图和伪三元相图等评价指标,优选枸杞籽油微乳的制剂处方;以乳滴粒径和粒度分布为指标,比较超声乳化法、高压乳匀法和自乳化法制备枸杞籽油微乳的不同特点。结果:优选的处方为1%枸杞籽油、1%吐温80、2%甘油;超声乳化法的工艺参数为超声功率480W,工作-间歇时间为10s-5s,超声时间25min,制得微乳的平均粒径为(74.6±45.3)nm(多分散系数(P.I)=0.368);高压乳匀法的工艺参数为均质压力500bar循环3次,制得微乳平均粒径为(69.0±31.5)nm(P.I=0.378);在相同处方比例下,自乳化法无法自发形成微乳,而当枸杞籽油:吐温80:甘油=1:7:2时,可自发形成微乳。结论:不同方法均能制得粒径小而均匀、外观透明有乳光的枸杞籽油微乳,但各法适用范围和特点不同。OBJECTIVE：To optimize the formulation of Boxthorn seed oil microemulsion,and to compare the 3 methods for the preparation of Boxthorn seed oil microemulsion.METHODS：The formulation of Boxthorn seed oil microemulsion was optimized with Boxthorn seed oil as oil phase using appearance,particle size of emulsion droplet,ternary phase diagram and pseudo-ternary phase diagram as index.The characteristics of Boxthorn seed oil microemulsion prepared by ultrasonic emulsification method,high pressure homogenization method and self-emulsification method were compared using particle size and granularity distribution of emulsion droplet.RESULTS：Optimized formulation was composed of 1% Boxthorn seed oil,1% Tween 80 and 2% glycerin.The parameters of ultrasonic emulsification technology were as follows：ultrasonic power 480w,working-interval duration of 10 s-5 s,ultrasonic time 25 min,mean particle size of（74.6±45.3） nm（P.I=0.368）.Microemulsion couldn＇t be formed by self-emulsification method for same formulation.Microemulsion could be formed autonomously when Boxthorn seed oil：Tween 80：glycerin was 1：7：2.CONCLUSION：The obtained microemulsion by three methods all shows even and nano grade particle size with transparent appearance.Each method has specific properties and application area.

关 键 词：枸杞籽油 微乳 伪三元相图 三元相图 

分 类 号：R969.1[医药卫生—药理学] R971.1[医药卫生—药学]