右旋美托咪啶对胸科手术麻醉苏醒期的影响  

Effect on the Patients with Thoracic Surgery Treated with Dexmedetomidine after General Anesthesia

作　　者：艾春雨[1] 蔡哲[1] 马虹[1] 

机构地区：[1]中国医科大学附属第一医院麻醉科,辽宁沈阳110001

出　　处：《中国血液流变学杂志》2012年第1期76-78,共3页Chinese Journal of Hemorheology

摘　　要：目的 观察右旋美托咪啶对胸科手术患者苏醒期间血流动力学指标及术后躁动,苏醒时间的影响.方法 选择40例ASAⅠ～Ⅱ级择期行胸科手术的患者,随机分为右旋美托咪啶组（D组）和对照组（C组）,每组20例.D组右旋美托咪啶1μg/kg用生理盐水配制成4mg/L的浓度,手术结束前30min用微量输液泵10min内静脉注射完毕.C组持续输注同等容量生理盐水作对照.观察患者麻醉前（T0）,苏醒时（T1）、拔管即刻（T2）、拔管后5min（T3）各时间点的平均动脉压和心率的数值,并记录呼吸恢复时间、睁眼时间和拔管时间.记录警觉镇静（OAA/S）评分及术后躁动情况.结果 D组麻醉苏醒期心血管反应稳定,C组血压、心率及收缩压在苏醒时、拔管即刻、拔管后均较术前和D组明显升高（P＜0.05＝.与C组比较,D组OAA/S评分及术后躁动发生率明显降低（P＜0.05＝.两组术毕自主呼吸恢复时间、睁眼时间、拔管时间差异无统计学意义（P＞0.05）.结论 右旋美托咪啶可有效减轻胸科手术患者拔管时的应激反应,降低术后躁动不安发生率.Objective To observe the effect of Dexmedetomidine on the patients with thoracic surgery during recovery period.Methods 40 patients with thoracic surgery were divided into two groups.Group D was injected Dexmedetomidine 1 Ix g/kg with minipump for 10 minutes at 30 minutes before the end of surgery.Group C was intravenous injection of physiological saline.MAP, HR were drawn following 4 time points：preoperative time（T0）,recovery time（T1）,extubation time（T2） and 5 minutes after extubation time（T3）.Spontaneous breathing recovery time,call time to eye opening,extubation time,OAA/S score and restlessness were recorded.Result MAP, HR of Group C at T1,T2,T3 was significantly increased than Group D and preoperative time（P 〈 0.05）. Compared with Group C,OAA/S score and restlessness were significantly decreased in Group D（P 〈 0.05）. Spontaneous breathing recovery time,call time to eye opening,extubation time were no significant difference among three groups（P 〉 0.05）.Conclusion Dexmedetomidine can suppress extubation stress and relieve restlessness after general anesthesia.

关 键 词：右旋美托咪啶 胸科手术 苏醒期 

分 类 号：R614.2[医药卫生—麻醉学]