微波合成噻二唑基-α-氨基膦酸酯及其生物活性研究  

Synthesis of thiadiazole-based-α-aminophosphonates using microwave irradiation and its activity

作　　者：曹宇[1] 陈岩[1] 史伯安[1] 

机构地区：[1]湖北民族学院化学与环境工程学院,湖北恩施445000

出　　处：《化学试剂》2012年第5期398-400,共3页Chemical Reagents

基　　金：湖北省教育厅重点项目(D20111902);湖北省高校校企合作资助项目(XD20100686)

摘　　要：以氨基硫脲为前体,用微波法合成了苯乙烯基1,3,4-噻二唑。再与不同的芳香醛及亚膦酸酯合成了一系列苯乙烯基1,3,4-噻二唑-5-氨基膦酸酯。所得产品均采用IR、1HNMR、UV、31PNMR及元素分析表征;生物活性实验表明,该类化合物都具有明显的杀菌活性。A series of thiadiazole-based-α-aminophosphonates were synthesized using microwave irradiation by 2-styryl-5- amino-1,3,4-thiadiazoles synthesized from thiosemicarbazide,with different aldehydes and phosphates. The products were confirmed by elementary analysis, UV, IR, ^1HNMR and ^31PNMR. The biological activity tests showed that they all have excellent fungicidal activities.

关 键 词：噻二唑 Α-氨基膦酸酯 微波辐射 

分 类 号：O621.29[理学—有机化学]