一种被动式微混合器的宏微建模方法与实验  

Macro-Micro Modeling Method and Experiment for a Passive Micromixer

作　　者：陈雪叶[1] 刘冲[1] 徐征[1] 

机构地区：[1]大连理工大学微纳米技术及系统辽宁省重点实验室,大连116085

出　　处：《纳米技术与精密工程》2012年第3期211-214,共4页Nanotechnology and Precision Engineering

基　　金：国家自然科学基金资助项目(20890024;91023046;91023017);国家重点基础研究发展计划(973计划)资助项目(2007CB714502);中央高校基本科研业务费专项资金资助项目(DUT11SM11)

摘　　要：建立了可用于被动式微混合器设计的宏微建模方法,利用分离变量法建立用于求解直通道内样品浓度分布的宏模型,采用宏模型计算微混合器的各段直通道内样品的浓度分布.运用有限元方法数值求解复杂的混合单元内样品的浓度分布,通过数值拟合和插值,交换宏模型与数值求解的计算结果.经过反复迭代,实现被动式微混合器的系统级求解.采用数控铣削在聚甲基丙烯酸甲脂(PMMA)平板上加工微通道,用热键合的方法实现微混合器盖片与基片的封装.在微混合器入口,输入3种不同浓度的荧光素钠盐溶液,形成样品浓度的准正态分布.采用激光诱导荧光观察和分析样品的混合效果.通过对比数值仿真和实验测试结果,验证了宏微建模计算方法的准确性.An available macro-micro modeling method was presented for a passive micromixer.The macro model based on separation of variables was used for calculating the concentration distribution in straight channels.The concentration distribution in complex mixing channels was calculated by finite element method.By interpolation and fitting between the results of macro model and numerical calculation,the concentration distribution in a certain microfluidic channel network can be evaluated at the system level.The microchannels were fabricated in a polymethyl methacrylate（PMMA） substrate via micro milling and sealed using another PMMA cover plate to enclose the microchannels.In the inlet,normal distribution was simulated using fluorescein sodium salt solution with three different concentrations.The mixing performance was detected using laser-induced fluorescence.The accuracy of the macro-micro modeling method was verified by comparison of simulation and experimental result,respectively.

关 键 词：微流控芯片 微混合器 宏微建模方法 数值计算 

分 类 号：TN402[电子电信—微电子学与固体电子学]