凝固酶阴性葡萄球菌医院感染现状及耐药性  

Current status of nosocomial infections caused by coagulase-negative Staphylococcusand drug resistance

作　　者：王小梅 申建维 

机构地区：[1]武汉市阳逻中心医院检验科,湖北武汉430415 [2]武汉钢铁公司第二职工医院检验科,湖北武汉430085

出　　处：《中华医院感染学杂志》2012年第9期1946-1947,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨凝固酶阴性葡萄球菌(CNS)医院感染及耐药现状,为临床治疗提供实验室依据。方法凝固酶阴性葡萄球菌培养与鉴定严格按照《全国临床检验操作规程》进行;药敏试验采用K-B法,结果依据CLSI最新折点进行评价。结果 136株CNS中表皮葡萄球菌和溶血葡萄球菌检出率最高,分别占50.7%、28.7%;耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)分离率为51.9%;MRCNS耐药率明显高于甲氧西林敏感凝固酶阴性葡萄球菌(MSCNS)。结论 CNS已成为医院感染重要的病原菌,MRCNS呈多药耐药,糖肽类抗菌药物是治疗MRCNS感染的首选药物。OBJECTIVE To study drug resistance status of nosocomial infections caused by coagulase-negative Staphylococcus（CNS） to offer experimental basis for clinical treatment.METHODS Referring to National Guide to Clinical Laboratory Procedures,CNS was cultured and identified.The drug susceptibility testings were performed by K-B method.The results were assessed according to the latest version of CLSI breakpoints.RESULTS Among 136 strains of CNS,the isolating rates of S.epidermidis（69 isolates,50.7%） and S.haemolyticus（39 isolates,28.7%） were the highest.The isolating rate of methicillin-resistant coagulase-negative Staphylococcus（MRCNS） was 51.9%.The drug-resistance rate of MRCNS was higher obviously than that of methicillin-susceptible coagulase-negative Staphylococcus（MSCNS）.CONCLUSION CNS has become one of the important pathogens of nosocomial infections.MRCNS shows multidrug-resistance.The peptide antibiotics are the first choice for treatment of MRCNS infections.

关 键 词：凝固酶阴性葡萄球菌 医院感染 耐药性 

分 类 号：R378[医药卫生—病原生物学]