川崎病患儿恢复期连续性随访观察  

Continual follow-up observation of Kawasaki disease in stage of recovery

作　　者：王小凤[1] 王从军[1] 谢小兵[2] 

机构地区：[1]荆楚理工学院医学院,湖北荆门448000 [2]湖南中医药大学第一附属医院检验科,湖南长沙410007

出　　处：《中国现代医学杂志》2012年第10期66-68,共3页China Journal of Modern Medicine

基　　金：湖北省教育厅2010年科研项目(No:Q20104302)

摘　　要：目的分析川崎病患儿临床特点,为川崎病的诊断、治疗和预后提供依据。方法对65例川崎病住院患儿恢复期进行连续性随访观察并检测相关实验室指标。结果川崎病的主要临床表现为发热、皮肤黏膜病变及淋巴结肿大,脏器损害以心脏、肺为主,心脏损害主要表现为冠状动脉扩张,其次为心电图异常。实验室改变主要为ESR和CR P增快,血小板升高,其他还包括肝功能异常等。静脉使用大剂量免疫丙种球蛋白后多数患儿在2个月内能完全恢复,包括冠状动脉扩张及相关实验室指标。川崎病的唯一永久损害是冠状动脉扩张,主要为重度扩张和形成冠状动脉瘤者。结论川崎病一般呈良性经过,静脉使用大剂量免疫丙种球蛋白球疗效较好,恢复期需进行长期随访,重度冠状动脉扩张或已形成冠状动脉瘤者预后较差。【Objective】 To analyze the clinical characteristics of Kawasaki disease,so as to provide the basis for diagnosis,treatment and prognosis.【Method】 65 patients in hospital with Kawasaki disease in restoration stage were followed up and the relevant laboratory parameters were tested.【Result】 The main clinical manifestations were fever,skin lesions and lymphadenectasis.The damage of organ was in heart,lungs mainly,and the main damage of heart was the dilatated coronary artery,followed by abnormal electrocardiogram.The main changes in the laboratory were the fast ESR、CRP,higher platelet and abnormal liver function.Most patients could recover in 2 months after using high-dose immune globulin through intravenous injection,so did coronary artery dilatation and related laboratory parameters.The only permanent damage of Kawasaki disease mainly was coronary artery dilatation and the formation of coronary aneurysm.【Conclusion】 Kawasaki disease usually has a benign process,the effect is satisfactory after using high-dose immune globulin through intravenous injection,and it needs a long-term follow-up in restoration stage,which has a poor prognosis for coronary artery dilatation and the formation of coronary aneurysm.

关 键 词：川崎病 恢复期 随访 

分 类 号：R543.3[医药卫生—心血管疾病]