老年高血压合并射血分数正常的心力衰竭患者血清PⅠCP、PⅢNP水平的变化  

Variation of PⅠCP and PⅢNP in the elderly with hypertension and heart failure with normal ejection fraction

作　　者：杜丽波[1] 方向明[1] 何兆初[1] 

机构地区：[1]广州医学院第一附属医院心内科,广东广州510120

出　　处：《中国老年学杂志》2012年第9期1789-1791,共3页Chinese Journal of Gerontology

基　　金：广东省自然科学基金资助项目(No.0400087)

摘　　要：目的探讨老年高血压患者血清Ⅰ型前胶原羧基末端肽(PICP)、Ⅲ型前胶原氨基末端肽(PⅢNP)水平与左室舒张功能(LVDF)的相关性。方法选取40例年龄≥65岁的高血压合并射血分数正常的心力衰竭(HFNEF),对照组取40例未合并HFPEF的高血压患者,分别测定其血清PICP、PⅢNP水平,并进行统计分析。结果合并HFPEF的老年高血压患者血清PICP、PⅢNP水平较对照组显著升高。结论血清PICP、PⅢNP水平与LVDF相关,可作为了解老年高血压患者心肌纤维化程度及LVDF的特异性指标。Objective To define variation of PⅢNP and PⅠCP in the elderly with hypertension and heart failure with normal ejection fraction（HFNEF）.Methods 40 patients（≥65 years old） with hypertension and HFPEF were selected,40 elderly with hypertension without HFNEF were selected as control.Serum of PⅠCP and PⅢNP were measured.Results Serum PⅠCP and PⅢNP were significantly increased in patients with hypertension and HFNEF.Conclusions Serum PⅠCP and PⅢNP is positively correlated with left ventricular diastolic function（LVDF）.PⅠCP and PⅢNP can be used to determine the degree of myocardial fibrosis degree and the LVDF in the elderly with hypertension.

关 键 词：Ⅰ型前胶原羧基末端肽 Ⅲ型前胶原氨基末端肽 射血分数 心力衰竭 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]