壳聚糖季铵盐用于止嗽定喘口服液原药水提液絮凝工艺研究  

Flocculation process of aqueous extracts of Zhisou Dingchuan oral solution with quaternary ammonium salt of chitosan

作　　者：孙泽沾[1] 孙姣[1,2] 秦莉[1] 康勇[1] 

机构地区：[1]天津大学化工学院,天津300072 [2]河北工业大学化工学院,天津300130

出　　处：《中国中药杂志》2012年第9期1212-1218,共7页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09301-008)

摘　　要：目的:研究壳聚糖季铵盐用于止嗽定喘口服液原药水提液除杂纯化的效果。方法:采用壳聚糖改性产物壳聚糖季铵盐对止嗽定喘口服液原药水提液进行絮凝处理,以麻黄碱、甘草酸保留率和药液浊度作为衡量指标,考察了絮凝剂用量、絮凝温度、搅拌速度、搅拌时间对絮凝效果的影响,并通过正交试验确定出最佳工艺条件。结果:最佳絮凝除杂工艺条件:药液温度30℃,壳聚糖季铵盐用量0.4 g.L-1,快速搅拌速度500 r.min-1,快速搅拌时间1 min,慢速搅拌速度50 r.min-1,慢速搅拌时间10 min,此时麻黄碱保留率为97.6%,甘草酸保留率为76.7%,药液浊度为1.1 NTU,放置30 d后的浊度为2.8NTU。结论:壳聚糖季铵盐可用于止嗽定喘口服原药水提液的絮凝纯化。Objective： To study the effect of quaternary ammonium salt of chitosan（HACC） in purifying aqueous extracts of Zhisou Dingchuan oral solution.Method： Modified quaternary ammonium salt of chitosan was used to flocculate aqueous extracts of Zhisou dingchuan oral solution,with turbidity degree and the retention rate of ephedrine and glycyrrhizin as indicators,to detect the influences of flocculant dosage,suspension temperature,mixing speed and time on flocculation effect.The optimum process conditions were found through orthogonal experimental design.Result： The optimum process conditions： the flocculation temperature 30 ℃,HACC′s dosage 0.4 g·L^-1,the fast mixing speed 500 r·min^-1 and its time 1 min,the slow mixing speed 50 r·min^-1 and it time 10 min.Under the conditions,the retention rate of ephedrine was 97.6%,the turbidity degree was 1.1 NTU and 2.8 NTU after 30 days.Conclusion： HACC can be used to purify aqueous extracts of Zhisou Dingchuan oral solution.

关 键 词：止嗽定喘口服液 壳聚糖季铵盐 絮凝 麻黄碱 浊度 

分 类 号：TQ461[化学工程—制药化工]