心踝血管指数早期筛查动脉硬化的应用价值  

Application of early diagnosis for arteriosclerosis by using cardio-ankle vascular index

作　　者：胡华青[1] 叶良平[1] 刘宁徽[2] 赵静[3] 韩卫星[3] 

机构地区：[1]安徽医科大学第一附属医院健康体检中心,合肥230022 [2]安徽医科大学第一附属医院血液净化科,合肥230022 [3]安徽医科大学第一附属医院心电心功能科,合肥230022

出　　处：《安徽医科大学学报》2012年第5期530-533,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省高等学校省级自然科学研究项目(编号:KJ2010B279)

摘　　要：目的对心踝血管指数(CAVI)早期筛查动脉硬化的有效性、适用性进行探讨,旨在寻求早期发现动脉粥样硬化性疾病的有价值的检测方法。方法对229例同时行CAVI检测和颈动脉超声检测的体检人群进行分析,并对相关检测结果进行统计学分析。结果 CAVI增高和颈动脉硬化呈正相关;通过受试者工作特征曲线(ROC曲线)分析CAVI对动脉硬化的预测价值,结果显示CAVI预测动脉硬化的ROC曲线下面积为0.774,最佳界值为8.1;将年龄分组后,在40～49岁年龄组CAVI阳性率高于颈动脉超声(P<0.05);在<40岁以及>50岁年龄组,二者阳性率差异无统计学意义。结论 CAVI是一种有效的早期评估动脉粥样硬化的检测指标,适用于在发生动脉硬化的早期或对于危险人群进行筛查;CAVI达8.1以上时就可能已有血管功能改变发生,应予以足够重视,将有利于早期发现血管病变,预防血管疾病突发事件的发生。Objective To investigate the suitability and effectiveness of early diagnosis of arteriosclerosis by using cardio-ankle vascular index（CAVI）,and to find out the valuable methods of early diagnosis for atherosclerosis.Methods 229 cases of health-care examination were recruited in our study.Statistic analysis was taken on relevant results of examination.Results Carotid atherosclerosis was positively correlated with CAVI.To analyze CAVI predictive value of arteriosclerosis through ROC curve,the area under the curve was 0.774,and the best cut-off value to predict arteriosclerosis was 8.1.Subjects were separated into different groups according to the age.The positive rates of CAVI were higher than that of carotid ultrasonography in group from 40 to 49 years old（P〈 0.05）.The difference between positive rates of CAVI and carotid ultrasonography were no statistic value in groups of younger than 40 years old and older than 50 years old.Conclusion CAVI is an effective inspective index of early diagnosis for arteriosclerosis,which can be used in early period of arteriosclerosis or check at-risk people.The function of blood vessels may have already been changed if the CAVI is over 8.1.The study will be useful to find out early angiopathy and to prevent emergencies caused by vascular disease.

关 键 词：心踝血管指数 动脉硬化 ROC曲线 

分 类 号：R543.5[医药卫生—心血管疾病]