弓形束导航技术的准确性与可靠性评价  

Reliability and accuracy of arcuate fasciculus navigation: analysis of 43 cases

作　　者：张家墅[1] 陈晓雷[1] 赵岩[1] 李昉晔[1] 郑刚[1] 李晋江[1] 张挺[1] 胡深[1] 许百男[1] 

机构地区：[1]解放军总医院神经外科,北京100853

出　　处：《南方医科大学学报》2012年第5期601-605,共5页Journal of Southern Medical University

基　　金：国家自然科学基金(30800349);北京市自然科学基金(7102145)~~

摘　　要：目的评价弓形束导航技术临床应用的准确性与可靠性。方法 43例语言区病变,分别于手术前后重建弓形束并评价语言功能。术前记录病变至弓形束的最短距离D1与术前失语指数AQ1,术后记录残腔至弓形束的最短距离D2与术后失语指数AQ2,分析D1与AQ1以及D2与AQ2的相关关系。术后随访时,评价患者语言功能。结果 43例患者的弓形束均得到重建,不同操作者重建的同一患者的弓形束重复性良好。D1与AQ(1P<0.001),D2与AQ(2P=0.001)均呈正的直线相关关系。术后随访,仅2例(4.7%)存在语言功能障碍。结论弓形束导航技术能够准确、可靠地重建和定位弓形束纤维,有助于保护语言功能。Objective To evaluate the reliability and accuracy of arcuate fasciculus（AF） navigation for AF localization and reconstruction.Methods Reconstruction of the AF and assessment of the aphasia quotient（AQ） were performed in 43 cases before and after surgical removal of lesions in the language area of the brain.The minimal distance between the AF and the lesion（D1）,preoperative AQ（AQ1）,the minimal distance between the AF and the surgical cavity（D2）,and the postoperative AQ（AQ2） were measured.Linear correlation analysis was conducted between D1 or D2 and the corresponding AQ1 or AQ2 to assess the relationship between the AF and language function.The language function of each patient was evaluated postoperatively.Results The AF was successfully reconstructed in all the cases.The tractography results of the identical AF generated by 3 different users showed good congruency.A positive linear correlation was demonstrated between D1 and AQ1（P0.001） and between D2 and AQ2（P=0.001）.Only two patients（4.7%） showed language deficits at postoperative follow-up.Conclusion AF navigation is a reliable and accurate technique for AF reconstruction and localization and helps to preserve the language function after surgical removal of lesions in the language area of the brain.

关 键 词：弓形束 纤维束导航 语言功能 

分 类 号：R445.2[医药卫生—影像医学与核医学]