补脾祛风方对脾虚型特应性皮炎患者血清总免疫球蛋白、嗜酸性粒细胞的影响  

Effects of Bupi-Qufeng decoction on serum TIgE and EOS of paitents with atopic dermatitis belonging to spleen deficiency syndrome

作　　者：郑永平[1] 陈高飞[1] 张玲[1] 王海棠[1] 孟娴[1] 

机构地区：[1]广东省中山市中医院皮肤科,528400

出　　处：《国际中医中药杂志》2012年第5期407-408,共2页International Journal of Traditional Chinese Medicine

基　　金：基金项目：中山市科技局2010年科技立项课题（项目编号：2010A056）

摘　　要：目的探讨补脾祛风方对特应性皮炎（atopicdemafifis，AD）血清总免疫球蛋白（TIgE）和嗜酸性粒细胞（EOS）的影响。方法将101例AD患者按随机数字表法分为治疗组50例和对照组51例，两组均给予复方当归薄荷膏外用，在此基础上治疗组服用补脾祛风方，对照组口服氯雷他定片。分别于治疗前及治疗4周后检测两组患者TIgE水平和EOS计数。结果治疗组患者在治疗后TIgE明显下降（t=8．0063，P〈0．001）；其下降幅度大于对照组治疗后（t=3．6434，P〈0．001）。治疗组患者治疗后EOS计数明显减少（t=3．0314，P〈0．01）；两组比较，差异有统计学意义（t=3．3331，P〈0．01）。结论补脾祛风方治疗AD可降低患者TigE、EOS水平。Objective To study the effect of Bupi-Qufeng decoction on total serum IgE （TIgE） and EOS counts ofatopic dermatitis （AD）. Methods A total of 101 cases were randomly recruited into a treatment group and a control group. During the treatment both groups were give Danggni-Bohe ointment for external use, and based on this, oral Bupi-Qufeng decoction was added in the treatment group and loratadine in the control group. TIgE level and EOS count were detected both before the treatment and four weeks after the treatment. Results TIgE in the treatment group decreased significantly after the treatment （t=8.0063, P〈0.001）, the decreased value of which was larger than the control group （t= 3.6434, P〈 0.001）. EOS count in the treatment group also obviously decreased after the treatment （t = 3.0314, P〈 0.01） ; the decreased value of which was also larger than the control group （t=3.3331, P〈0.01）. Conclusion Bupi-Qufeng decoction could decrease TIgE and EOS level of AD patient, while the therapeutic mechanism needed further research.

关 键 词：特应性皮炎 补脾祛风方 总免疫球蛋白 嗜酸性粒细胞 

分 类 号：R725.6[医药卫生—儿科]