快速老化小鼠SAM-P/8出现类帕金森病现象初探  

Senescence Accelerated Mouse SAM-P/8 Appears Syndrome Similar to Parkinson's Disease

作　　者：刘云鹤[1,2] 苗珍花[3] 李震[1] 成海燕[1] 曲由[1,2] 刘阿庆[1,2] 许文斌[1,2] 温明菲[1,2] 尚磊[1,2] 陈璐[1,2] 韩景献[1] 于建春[1] 

机构地区：[1]天津中医药大学第一附属医院韩景献全国名老中医药专家传承工作室,天津300193 [2]天津中医药大学,天津300193 [3]宁夏医科大学基础医学院人体解剖与组织胚胎学教研室,银川750004

出　　处：《实验动物科学》2012年第1期6-8,17,共4页Laboratory Animal Science

基　　金：国家自然科学青年基金(No.30901927);教育部新世纪优秀人才计划(No.NCET-07-0616);高等学校博士学科点专项科研基金(No.20101210110005);天津市应用基础及前沿技术研究计划(No.09JCYBJC12600)

摘　　要：目的探讨快速老化小鼠SAM-P/8的同向旋转现象与帕金森病动物模型的相关性。方法取发作旋转行为的7月龄雄性SAM-P/8和同源对照SAM-R/1小鼠各6只,分为旋转组和正常对照组两组,首先采用老化度评价标准对其老化度进行评定,其次根据帕金森病动物模型造模标准对其旋转行为进行评定。结果同月龄SAM-P/8的老化度高于SAM-R/1;SAM-P/8出现可重复的同向右侧旋转,频率为60 r/min,符合帕金森病动物模型造模成功的标准,SAM-R/1无旋转现象出现。结论初步认定SAM-P/8的同向旋转现象为类帕金森病现象,对帕金森病研究有重要意义。Objective To explore the relativity between the rotational behavior of Parkinson＇s disease mice model and the spontaneous rotational behavior to the same direction in senescence accelerated mouse SAM-P/8.Methods The mice were divided into 2 groups ：1.Rotation group includes 6 Male SAM-P/8 at 7-month old that appear rotational behaviors2.Normal control group includes 6 Male SAM-R/1 at 7-month.First applies ＂the scores of aging＂ to study the aging symptoms;then evaluate their characteristics of behavior of rotation to the same direction by PD mice model standard.Results Compared with SAM-R/1 control group,SAM-P/8 group appeared obvious aging sign and symptoms at 7 months old;SAM-P/8 appear steady rotational behavior to the same direction,the frequency is 60 rotations per minute.This kind of rotation behavior coincides with PD mice model standard.Conclusions Senescence accelerated mouse SAM-P/8 appears syndrome similar to PD.This discovery will make sense to the research of PD.

关 键 词：SAM-P/8小鼠 同向旋转 帕金森病 

分 类 号：Q95-33[生物学—动物学]